Liver sinusoidal endothelial cells (LSECs) are highly specialized endothelial cells
representing the interface between blood cells on the one side and hepatocytes and hepatic …

99% of administered nanoparticles will accumulate and sequester in the liver after
administration into the body. This results in reduced delivery to the targeted diseased tissue …

The demands that are imposed on the liver as a result of its function as a metabolic organ
that extracts nutrients and clears gut-derived microbial products from the blood are met by a …

Transposons are mobile genetic elements evolved to execute highly efficient integration of
their genes into the genomes of their host cells. These natural DNA transfer vehicles have …

Liver fibrosis is a common feature of sustained liver injury and represents a major public
health problem worldwide. Fibrosis is an active research field and discoveries in the last …

The widespread clinical implementation of gene therapy requires the ability to stably
integrate genetic information through gene transfer vectors in a safe, effective, and …

The stable introduction of therapeutic transgenes into human cells can be accomplished
using viral and nonviral approaches. Transduction with clinical-grade recombinant viruses …

Protein kinase CK2, a protein serine/threonine kinase, plays a global role in activities related
to cell growth, cell death, and cell survival. CK2 has a large number of potential substrates …

Nanomedicine is certainly one of the scientific and technological challenges of the coming
years. In particular, biodegradable nanoparticles formulated from poly (D, L-lactide-co …

Over the past decade, the Sleeping Beauty (SB) transposon system has been developed as
the leading non-viral vector for gene therapy. This vector combines the advantages of …