Drug designing and development is an important area of research for pharmaceutical
companies and chemical scientists. However, low efficacy, off-target delivery, time …

Systems biology is an integrative discipline connecting the molecular components within a
single biological scale and also among different scales (eg cells, tissues and organ systems) …

A systems pharmacology model typically integrates pharmacokinetic, biochemical network,
and systems biology concepts into a unifying approach. It typically consists of a large …

This document was developed to enable greater consistency in the practice, application,
and documentation of Model‐Informed Drug Discovery and Development (MID3) across the …

This paper describes the development and characterization of a microphysiology platform
for drug safety and efficacy in liver models of disease that includes a human, 3D …

The explosive growth in medical devices, imaging and diagnostics, computing, and
communication and information technologies in drug development and healthcare has …

Despite the remarkable advances in cancer diagnosis, treatment, and management over the
past decade, malignant tumors remain a major public health problem. Further progress in …

Ischemic stroke (IS) is a multifactorial and heterogeneous neurological disorder with high
rate of death and long-term impairment. Despite years of studies, there are still no stroke …

Abstract Herb pair Danggui-Honghua has been frequently used for treatment of blood stasis
syndrome (BSS) in China, one of the most common clinical pathological syndromes in …

Complex diseases like cancer are regulated by large, interconnected networks with many
pathways affecting cell proliferation, invasion, and drug resistance. However, current cancer …