In eukaryotes, almost all RNA species are processed at their 3′ ends and most mRNAs are
polyadenylated in the nucleus by canonical poly (A) polymerases. In recent years, several …

Reactive oxygen species (ROS) and reactive nitrogen species (RNS) incessantly produced
as by-products of metabolism play significant roles in seed physiology. ROS (hydroxyl …

Two populations of alveolar macrophages (AMs) coexist in the inflamed lung: resident AMs
that arise during embryogenesis, and recruited AMs that originate postnatally from …

Cancer cells typically exhibit aberrant DNA methylation patterns that can drive malignant
transformation. Whether cancer cells are dependent on these abnormal epigenetic …

Apoptosis is a tightly coordinated cell death program that damages mitochondria, DNA,
proteins, and membrane lipids. Little is known about the fate of RNA as cells die. Here, we …

We previously reported that up to 50% of messenger RNAs (mRNA) are oxidatively
damaged in the affected area of Alzheimer's disease (AD) brains. The role of RNA oxidation …

Circulating tumor cells (CTC) mediate metastatic spread of many solid tumors and
enumeration of CTCs is currently used as a prognostic indicator of survival in metastatic …

During apoptosis there is a substantial reduction in the rate of protein synthesis, and yet
some mRNAs avoid this translational inhibition. To determine the impact that receptor …

Understanding of seed ageing, which leads to viability loss during storage, is vital for ex situ
plant conservation and agriculture alike. Yet the potential for regulation at the transcriptional …

In recent years, yeast was confirmed as a useful eukaryotic model system to decipher the
complex mechanisms and networks occurring in higher eukaryotes, particularly in …