In diffusion weighted imaging (DWI), the apparent diffusion coefficient (ADC) has been
recognized as a useful and sensitive surrogate for cell density, paving the way for non …

Imaging is an indispensable tool for brain tumour diagnosis, surgical planning, and follow-
up. Definite diagnosis, however, often demands histopathological analysis of microscopic …

Principles from multidimensional NMR spectroscopy, and in particular solid-state NMR, have
recently been transferred to the field of diffusion MRI, offering non-invasive characterization …

Monitoring time dependence with diffusion MRI yields observables sensitive to compartment
sizes (restricted diffusion) and membrane permeability (water exchange). However …

In magnetic resonance imaging (MRI), spatial field gradients are applied along each axis to
encode the location of the nuclear spin in the frequency domain. During recent years, the …

Abstract Diffusion Magnetic Resonance Imaging (dMRI) is one of the most important
contemporary non-invasive modalities for probing tissue structure at the microscopic scale …

Transmembrane water exchange, including intra-to-extravascular and intra-to-extracellular
ones, are potential biomarkers in the diagnosis and understanding of cancers, brain …

For its size, the brain is the most metabolically active organ in the body. Most of its energy
demand is used to maintain stable homeostatic physiological conditions. Altered …

Purpose Reperfusion therapy enables effective treatment of ischemic stroke presenting
within 4–6 hours. However, tissue progression from ischemia to infarction is variable, and …

Purpose To assess the feasibility of using diffusion‐time‐dependent diffusional kurtosis
imaging (tDKI) to measure cellular‐interstitial water exchange time (τex) in tumors, both in …