Cartilage homeostasis is governed by articular chondrocytes via their ability to modulate
extracellular matrix production and degradation. In turn, chondrocyte activity is regulated by …

Subchondral bone and the synovium play an important role in the initiation and progression
of OA. MRI often permits an early detection of synovial hypertrophy and bone marrow …

Articular cartilage is a load‐bearing tissue playing a crucial mechanical role in diarthrodial
joints, facilitating joint articulation, and minimizing wear. The significance of biomechanical …

Although cartilage degradation is the characteristic feature of osteoarthritis (OA), it is now
recognized that the whole joint is involved in the progression of OA. In particular, the …

Transforming growth factor-β (TGFβ) is a pleiotropic cytokine that is important in the
regulation of joint homeostasis and disease. TGFβ signalling is induced by loading and has …

Objective This study was to investigate the functional role of RNA methyltransferase
METTL3, an enzyme catalyzes the formation of N6-methyladenosine (m6A) on the target …

Osteoarthritis (OA) is currently the most widespread musculoskeletal condition and primarily
affects weight-bearing joints such as the knees and hips. Importantly, knee OA remains a …

Osteoarthritis (OA) is a progressive degenerative disease of articular cartilage and
surrounding tissues, and is associated with both advanced age and joint injury …

Developing effective treatment for osteoarthritis (OA), a prevalent and disabling disease, has
remained a challenge, primarily because of limited understanding of its pathogenesis and …

Osteoarthritis (OA) is the most common chronic joint disorder worldwide, with a high
personal burden for the patients and an important socio-economic impact. Current therapies …