Exosomal composition, biogenesis and profiling using point-of-care diagnostics—implications for cardiovascular disease

D Burtenshaw, B Regan, K Owen, D Collins… - Frontiers in cell and …, 2022 - frontiersin.org
Arteriosclerosis is an important age-dependent disease that encompasses atherosclerosis,
in-stent restenosis (ISR), pulmonary hypertension, autologous bypass grafting and …

Does remote ischaemic conditioning reduce inflammation? A focus on innate immunity and cytokine response

L Pearce, SM Davidson, DM Yellon - Basic research in cardiology, 2021 - Springer
The benefits of remote ischaemic conditioning (RIC) have been difficult to translate to
humans, when considering traditional outcome measures, such as mortality and heart …

Cardioprotection by remote ischemic conditioning is transferable by plasma and mediated by extracellular vesicles

TR Lassen, J Just, MV Hjortbak, NR Jespersen… - Basic research in …, 2021 - Springer
Background Remote ischemic conditioning (RIC) by brief periods of limb ischemia and
reperfusion protects against ischemia–reperfusion injury. We studied the cardioprotective …

[HTML][HTML] Extracellular vesicles from patients with Acute Coronary Syndrome impact on ischemia-reperfusion injury

F D'Ascenzo, S Femmino, F Ravera, F Angelini… - Pharmacological …, 2021 - Elsevier
The relevance of extracellular vesicles (EV) as mediators of cardiac damage or recovery
upon Ischemia Reperfusion Injury (IRI) and Remote Ischemic PreConditioning (RIPC) is …

Role of extracellular vesicles in atherosclerosis: An update

PM Coly, CM Boulanger - Journal of Leukocyte Biology, 2022 - academic.oup.com
Extracellular vesicles (EVs) are membrane particles released by most cell types in response
to different stimuli. They are composed of a lipid bilayer that encloses a wide range of …

Red blood cell transfusion-related dynamics of extracellular vesicles in intensive care patients: a prospective subanalysis

P Raeven, K Karlhofer, LS Sztulman, J Brugger… - Scientific Reports, 2024 - nature.com
Extracellular vesicles (EVs) accumulate during packed red blood cell (PRBC) storage. To
date, the involvement of EVs in transfusion-related immunomodulation (TRIM) has not been …

The role of plasma extracellular vesicles in remote ischemic conditioning and exercise-induced ischemic tolerance

T Gu, J Just, KT Stenz, Y Yan, P Sieljacks… - International Journal of …, 2022 - mdpi.com
Ischemic conditioning and exercise have been suggested for protecting against brain
ischemia-reperfusion injury. However, the endogenous protective mechanisms stimulated …

Challenges facing the clinical translation of cardioprotection: 35 years after the discovery of ischemic preconditioning

C Penna, S Comita, F Tullio, G Alloatti… - Vascular Pharmacology, 2022 - Elsevier
Since coronary reperfusion was introduced into clinical practice in the late 1970s, the further
translation of several successful animal experiments on cardioprotection into clinical …

Cardiosome-mediated protection in myocardial ischemia

M Arroyo-Campuzano, A Gil-Hernández… - Clinica Chimica …, 2023 - Elsevier
Cardiosomes, exosomes released in cardiospheres by cardiomyocytes and progenitor cells,
communicate locally and at a distance from different tissues, promoting beneficial cellular …

Pathways for cardioprotection in perspective: focus on remote conditioning and extracellular vesicles

S Comità, C Rubeo, M Giordano, C Penna, P Pagliaro - Biology, 2023 - mdpi.com
Simple Summary Despite the development of cutting-edge treatments, coronary artery
disease (CAD) morbidity and mortality rates remain present at high levels. New …