[HTML][HTML] Inflammatory processes in alzheimer's disease—pathomechanism, diagnosis and treatment: a review

B Twarowski, M Herbet - International journal of molecular sciences, 2023 - mdpi.com
Alzheimer's disease is one of the most commonly diagnosed cases of senile dementia in the
world. It is an incurable process, most often leading to death. This disease is multifactorial …

Dietary polyphenols in age‐related macular degeneration: protection against oxidative stress and beyond

E Pawlowska, J Szczepanska… - Oxidative medicine …, 2019 - Wiley Online Library
Age‐related macular degeneration (AMD) is a multifactorial disease of the retina featured by
degeneration and loss of photoreceptors and retinal pigment epithelium (RPE) cells with …

Using Mendelian randomization to evaluate the causal relationship between serum C-reactive protein levels and age-related macular degeneration

X Han, JS Ong, J An, AW Hewitt, P Gharahkhani… - European Journal of …, 2020 - Springer
Serum C-reactive protein (CRP), an important inflammatory marker, has been associated
with age-related macular degeneration (AMD) in observational studies; however, the …

[HTML][HTML] The impact of non-additive genetic associations on age-related complex diseases

M Guindo-Martínez, R Amela, S Bonàs-Guarch… - Nature …, 2021 - nature.com
Genome-wide association studies (GWAS) are not fully comprehensive, as current strategies
typically test only the additive model, exclude the X chromosome, and use only one …

On the origin of proteins in human drusen: The meet, greet and stick hypothesis

AA Bergen, S Arya, C Koster, MG Pilgrim… - Progress in Retinal and …, 2019 - Elsevier
Retinal drusen formation is not only a clinical hallmark for the development of age-related
macular degeneration (AMD) but also for other disorders, such as Alzheimer's disease and …

[HTML][HTML] Mendelian randomization analyses in ocular disease: a powerful approach to causal inference with human genetic data

J Li, C Li, Y Huang, P Guan, D Huang, H Yu… - Journal of Translational …, 2022 - Springer
Ophthalmic epidemiology is concerned with the prevalence, distribution and other factors
relating to human eye disease. While observational studies cannot avoid confounding …

[HTML][HTML] Biomarkers for the progression of intermediate age-related macular degeneration

EM Lad, RP Finger, R Guymer - Ophthalmology and Therapy, 2023 - Springer
Age-related macular degeneration (AMD) is a leading cause of severe vision loss
worldwide, with a global prevalence that is predicted to substantially increase. Identifying …

[HTML][HTML] Apolipoprotein ε in brain and retinal neurodegenerative diseases

M Abyadeh, V Gupta, JA Paulo, S Sheriff… - Aging and …, 2023 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is the most common form of dementia that remains incurable and
has become a major medical, social, and economic challenge worldwide. AD is …

[HTML][HTML] Interlink between inflammation and oxidative stress in age-related macular degeneration: role of complement factor H

S Romero-Vazquez, V Llorens, A Soler-Boronat… - Biomedicines, 2021 - mdpi.com
Age-related macular degeneration (AMD) heads the list of legal blindness among the elderly
population in developed countries. Due to the complex nature of the retina and the variety of …

[HTML][HTML] C-reactive protein causes adult-onset obesity through chronic inflammatory mechanism

Q Li, QI Wang, W Xu, Y Ma, Q Wang… - Frontiers in cell and …, 2020 - frontiersin.org
Obesity is characterized by low-grade chronic inflammation. As an acute-phase reactant to
inflammation and infection, C-reactive protein (CRP) has been found to be the strongest …