Alternative polyadenylation of mRNA precursors
Alternative polyadenylation (APA) is an RNA-processing mechanism that generates distinct
3′ termini on mRNAs and other RNA polymerase II transcripts. It is widespread across all …
3′ termini on mRNAs and other RNA polymerase II transcripts. It is widespread across all …
RNA splicing factors as oncoproteins and tumour suppressors
H Dvinge, E Kim, O Abdel-Wahab… - Nature Reviews Cancer, 2016 - nature.com
The recent genomic characterization of cancers has revealed recurrent somatic point
mutations and copy number changes affecting genes encoding RNA splicing factors. Initial …
mutations and copy number changes affecting genes encoding RNA splicing factors. Initial …
YTHDC1 mediates nuclear export of N6-methyladenosine methylated mRNAs
N 6-methyladenosine (m6A) is the most abundant internal modification of eukaryotic
messenger RNA (mRNA) and plays critical roles in RNA biology. The function of this …
messenger RNA (mRNA) and plays critical roles in RNA biology. The function of this …
Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and splicing during mouse oocyte development
SD Kasowitz, J Ma, SJ Anderson, NA Leu, Y Xu… - PLoS …, 2018 - journals.plos.org
The N 6-methyladenosine (m6A) modification is the most prevalent internal RNA
modification in eukaryotes. The majority of m6A sites are found in the last exon and 3'UTRs …
modification in eukaryotes. The majority of m6A sites are found in the last exon and 3'UTRs …
UMI-tools: modeling sequencing errors in Unique Molecular Identifiers to improve quantification accuracy
Unique Molecular Identifiers (UMIs) are random oligonucleotide barcodes that are
increasingly used in high-throughput sequencing experiments. Through a UMI, identical …
increasingly used in high-throughput sequencing experiments. Through a UMI, identical …
Sequence, structure, and context preferences of human RNA binding proteins
D Dominguez, P Freese, MS Alexis, A Su, M Hochman… - Molecular cell, 2018 - cell.com
RNA binding proteins (RBPs) orchestrate the production, processing, and function of
mRNAs. Here, we present the affinity landscapes of 78 human RBPs using an unbiased …
mRNAs. Here, we present the affinity landscapes of 78 human RBPs using an unbiased …
An atlas of alternative polyadenylation quantitative trait loci contributing to complex trait and disease heritability
Genome-wide association studies have identified thousands of noncoding variants
associated with human traits and diseases. However, the functional interpretation of these …
associated with human traits and diseases. However, the functional interpretation of these …
Long noncoding RNA MALAT1 promotes hepatocellular carcinoma development by SRSF1 upregulation and mTOR activation
Several long noncoding RNAs (lncRNA) are abrogated in cancer but their precise
contributions to oncogenesis are still emerging. Here we report that the lncRNA MALAT1 is …
contributions to oncogenesis are still emerging. Here we report that the lncRNA MALAT1 is …
The master energy homeostasis regulator PGC-1α exhibits an mRNA nuclear export function
PGC-1α plays a central role in maintaining mitochondrial and energy metabolism
homeostasis, linking external stimuli to transcriptional co-activation of genes involved in …
homeostasis, linking external stimuli to transcriptional co-activation of genes involved in …
RNA modifications and structures cooperate to guide RNA–protein interactions
CJT Lewis, T Pan, A Kalsotra - Nature reviews Molecular cell biology, 2017 - nature.com
An emerging body of evidence indicates that post-transcriptional gene regulation relies not
only on the sequence of mRNAs but also on their folding into intricate secondary structures …
only on the sequence of mRNAs but also on their folding into intricate secondary structures …