Lysine acetylation creates docking sites for epigenetic reader domains of BET bromodomain
proteins that have emerged as principal regulators of linage specific gene transcription. The …

Extracellular signal-regulated kinase 5 (ERK5) belongs to the mitogen-activated protein
kinase (MAPK) family that consists of highly conserved enzymes expressed in all eukaryotic …

Abstract Doublecortin like kinase 1 (DCLK1) is an understudied kinase that is upregulated in
a wide range of cancers, including pancreatic ductal adenocarcinoma (PDAC). However …

Glioblastoma (GBM) is the most common primary adult brain tumor. Despite extensive
efforts, the median survival for GBM patients is approximately 14 months. GBM therapy could …

Abstract Bromodomain‐containing protein 4 (BRD4), as the most studied member of the
bromodomain and extra‐terminal (BET) family, is a chromatin reader protein interpreting …

The mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase 1/2
(ERK1/2) signaling pathway is widely activated by a variety of extracellular stimuli, and its …

Multitargeting involves the application of molecules that are deliberately intended to bind to
two or more unrelated cellular targets with high affinity. In epigenetic chemical biology and …

Despite advances in its treatment, lung cancer still represents the most common and lethal
tumor. Because of that, efforts to decipher the pathophysiological actors that may promote …

Melanoma is the deadliest skin cancer with a very poor prognosis in advanced stages.
Although targeted and immune therapies have improved survival, not all patients benefit …

Endometrial cancer (EC) is the most common type of gynecologic cancer in women of
developed countries. Despite surgery combined with chemo-/radiotherapy regimens, overall …