Genetic analyses have shaped much of our understanding of cancer. However, it is
becoming increasingly clear that cancer cells display features of normal tissue organization …

Phenotypic and functional heterogeneity arise among cancer cells within the same tumour
as a consequence of genetic change, environmental differences and reversible changes in …

Chemotherapy-resistant human acute myeloid leukemia (AML) cells are thought to be
enriched in quiescent immature leukemic stem cells (LSC). To validate this hypothesis in …

Acute myeloid leukemia (AML) manifests as phenotypically and functionally diverse cells,
often within the same patient. Intratumor phenotypic and functional heterogeneity have been …

The BCL2 inhibitor venetoclax (VEN) in combination with azacitidine (5-AZA) is currently
transforming acute myeloid leukemia (AML) therapy. However, there is a lack of clinically …

Here we demonstrate that in a niche-like coculture system, cells from both primary and
cultured acute myeloid leukemia (AML) sources take up functional mitochondria from murine …

Acute myeloid leukaemia (AML) is a disorder characterized by a clonal proliferation derived
from primitive haematopoietic stem cells or progenitor cells. Abnormal differentiation of …

The cancer stem cell (CSC) model has been established as a cellular mechanism that
contributes to phenotypic and functional heterogeneity in diverse cancer types. Recent …

The differentiation of tumorigenic cancer stem cells into nontumorigenic cancer cells confers
heterogeneity to some cancers beyond that explained by clonal evolution or environmental …

The cancer stem cell (CSC) concept derives from the fact that cancers are dysregulated
tissue clones whose continued propagation is vested in a biologically distinct subset of cells …