TGFβ in pancreas and colorectal cancer: opportunities to overcome therapeutic resistance
AM Johansen, SD Forsythe, CT McGrath… - Clinical Cancer …, 2024 - aacrjournals.org
TGFβ is a pleiotropic signaling pathway that plays a pivotal role in regulating a multitude of
cellular functions. TGFβ has a dual role in cell regulation where it induces growth inhibition …
cellular functions. TGFβ has a dual role in cell regulation where it induces growth inhibition …
[HTML][HTML] Crosstalk Within the Intestinal Epithelium: Aspects of Intestinal Absorption, Homeostasis, and Immunity
Gut health is crucial in many ways, such as in improving human health in general and
enhancing production in agricultural animals. To maximize the effect of a healthy …
enhancing production in agricultural animals. To maximize the effect of a healthy …
Enterocyte-like differentiation defines metabolic gene signatures of CMS3 colorectal cancers and provides therapeutic vulnerability
A Torang, AB Kirov, V Lammers, K Cameron… - Nature …, 2025 - nature.com
Colorectal cancer (CRC) is stratified into four consensus molecular subtypes (CMS1-4).
CMS3 represents the metabolic subtype, but its wiring remains largely undefined. To identify …
CMS3 represents the metabolic subtype, but its wiring remains largely undefined. To identify …
Retinoblastoma-binding Protein 9 Suppresses Intestinal Inflammation and Inflammation-induced Tumorigenesis in Mice
K Hamada, Y Nakanishi, Y Muta, M Omatsu… - Cellular and Molecular …, 2024 - Elsevier
BACKGROUND & AIMS Retinoblastoma-binding protein 9 (RBBP9) was initially reported as
cell cycle regulator via RB/E2F. Accumulating evidence has revealed the importance of …
cell cycle regulator via RB/E2F. Accumulating evidence has revealed the importance of …
Noninvasive Stratification of Colon Cancer by Multiplex PET Imaging
G Malviya, TRM Lannagan, E Johnson… - Clinical Cancer …, 2024 - AACR
Purpose: The current approach for molecular subtyping of colon cancer relies on gene
expression profiling, which is invasive and has limited ability to reveal dynamics and spatial …
expression profiling, which is invasive and has limited ability to reveal dynamics and spatial …
Management of malignant T1 colorectal cancer polyps: results from a 10‐year prospective observational study
MS Johnstone, ST McSorley… - Colorectal Disease, 2023 - Wiley Online Library
Aim The recurrence risk associated with residual malignant cells (bowel wall/regional
nodes) following T1 colorectal cancer (CRC) polypectomy must be weighed against …
nodes) following T1 colorectal cancer (CRC) polypectomy must be weighed against …
Toxicological assessments based on intestine 3D organoids reveal environmental low-dose nanosized microplastics (NPs) exposure aggravates radiation-induced …
P Guo, C Bai, L Xuan, W Yi, J Luo, H Pan, W Chen… - Chemosphere, 2025 - Elsevier
Background Intestinal organoid has emerged as an energetic tool for modeling intestine
physiology and relevant diseases in vitro. Here, we reported that development of intestinal …
physiology and relevant diseases in vitro. Here, we reported that development of intestinal …
Impact of molecular status on cytoreductive surgery for peritoneal metastases from colorectal cancer
Y Zhong, K Yang, X Qin, R Luo… - Clinics in Colon and …, 2023 - thieme-connect.com
Colorectal cancer peritoneal metastases (CRC-PM) are present in 5 to 15% of instances of
CRC, and the overall survival (OS) of patients with CRC-PM is much lower than that of …
CRC, and the overall survival (OS) of patients with CRC-PM is much lower than that of …
[HTML][HTML] Application of Molecular Profiling in Colorectal Cancer Surgery: Impact of Molecular Status on Cytoreductive Surgery for Peritoneal Metastases from …
Y Zhong, K Yang, X Qin, R Luo… - Clinics in Colon and …, 2023 - ncbi.nlm.nih.gov
Colorectal cancer peritoneal metastases (CRC-PM) are present in 5 to 15% of instances of
CRC, and the overall survival (OS) of patients with CRC-PM is much lower than that of …
CRC, and the overall survival (OS) of patients with CRC-PM is much lower than that of …