Sex hormone-binding globulin (SHBG) as an early biomarker and therapeutic target in polycystic ovary syndrome

X Qu, R Donnelly - International journal of molecular sciences, 2020 - mdpi.com
Human sex hormone-binding globulin (SHBG) is a glycoprotein produced by the liver that
binds sex steroids with high affinity and specificity. Clinical observations and reports in the …

Testosterone, sex hormone-binding globulin and the metabolic syndrome: a systematic review and meta-analysis of observational studies

JS Brand, I Van Der Tweel, DE Grobbee… - International journal …, 2011 - academic.oup.com
Background Accumulating evidence suggests a sex-dependent role of circulating
testosterone in the metabolic syndrome (MetS). Methods We conducted a meta-analysis of …

Hyperandrogenism in polycystic ovarian syndrome and role of CYP gene variants: a review

S Ashraf, M Nabi, F Rashid, S Amin - Egyptian Journal of Medical …, 2019 - Springer
Background Polycystic ovary syndrome (PCOS) is a multifactorial endocrine disorder
characterized by anovulation, hyperandrogenism, and polycystic ovarian morphology. The …

Sex hormone binding globulin-an important biomarker for predicting PCOS risk: A systematic review and meta-analysis

R Deswal, A Yadav, AS Dang - Systems biology in reproductive …, 2018 - Taylor & Francis
Sex hormone-binding globulin (SHBG) is a glycoprotein which regulates bioavailability of
sex steroid hormones. Interest in SHBG has escalated in recent years because of its inverse …

Metabolic characteristics of women with polycystic ovaries and oligo‐amenorrhoea but normal androgen levels: implications for the management of polycystic ovary …

TM Barber, JAH Wass, MI McCarthy… - Clinical …, 2007 - Wiley Online Library
Objective Application of the newly introduced Rotterdam criteria for polycystic ovary
syndrome (PCOS) generates four phenotypic subgroups, defined by the presence/absence …

Relationship between androgen levels and blood pressure in young women with polycystic ovary syndrome

MJ Chen, WS Yang, JH Yang, CL Chen, HN Ho… - …, 2007 - Am Heart Assoc
The role of testosterone on the development of hypertension is controversial, especially in
women with polycystic ovary syndrome (PCOS) who have higher prevalence of obesity and …

Androgen excess: Investigations and management

D Lizneva, L Gavrilova-Jordan, W Walker… - Best practice & research …, 2016 - Elsevier
Androgen excess (AE) is a key feature of polycystic ovary syndrome (PCOS) and results in,
or contributes to, the clinical phenotype of these patients. Although AE will contribute to the …

Endocrine and liver interaction: the role of endocrine pathways in NASH

P Loria, L Carulli, M Bertolotti, A Lonardo - … reviews Gastroenterology & …, 2009 - nature.com
This article reviews evidence that causally links hormonal disorders with hepatobiliary
disease, and gives particular focus to nonalcoholic steatohepatitis (NASH). The downstream …

The relationship between anti-Müllerian hormone, androgen and insulin resistance on the number of antral follicles in women with polycystic ovary syndrome

MJ Chen, WS Yang, CL Chen, MY Wu… - Human …, 2008 - academic.oup.com
BACKGROUND Anti-Müllerian hormone (AMH) is a biomarker that predicts the number of
antral follicles and is involved in follicle arrest for women with polycystic ovary syndrome …

Dietary modification for reproductive health in women with polycystic ovary syndrome: a systematic review and meta-analysis

Y Shang, H Zhou, R He, W Lu - Frontiers in endocrinology, 2021 - frontiersin.org
Objective Diet has been reported as the first-line management of polycystic ovary syndrome
(PCOS). However, the relationship between diet and fertility in PCOS is still controversial …