Pathogenic animal trypanosomes affecting livestock have represented a major constraint to
agricultural development in Africa for centuries, and their negative economic impact is …

Melarsoprol and pentamidine represent the two main classes of drugs, the arsenicals and
diamidines, historically used to treat the diseases caused by African trypanosomes: sleeping …

The twentieth century ended with human African trypanosomiasis (HAT) epidemics raging
across many parts of Africa. Resistance to existing drugs was emerging, and many programs …

With the incidence of sleeping sickness in decline and genuine progress being made
towards the WHO goal of eliminating sleeping sickness as a major public health concern …

Three of the four currently approved drugs for the treatment of African trypanosomiasis
(sleeping sickness) were developed over 50 years ago. All of the current therapies are …

Leishmaniasis, in its variety of visceral (VL), cutaneous (CL) and mucocutaneous (MCL)
forms, directly affects about 2 million people per annum, with approximately 350 million …

This review discusses the challenges of chemotherapy for human African trypanosomiasis
(HAT). The few drugs registered for use against the disease are unsatisfactory for a number …

The protozoan parasites Trypanosoma brucei and Trypanosoma cruzi are the causative
agents of African trypanosomiasis and Chagas disease, respectively. These are debilitating …

Despite the many decades of use of most of the current trypanocides, we know little of their
mode of action. This may in part be because most of these will act on multiple targets once …

Diamidines, and pentamidine in particular, have a long history as valuable
chemotherapeutic agents against infectious disease. Their selectivity is due mostly to …