Cholinergic neurons comprise a small population of cells in the striatum but have
fundamental roles in fine tuning brain function, and in the etiology of neurological and …

Psychiatric disorders are clinically heterogeneous and debilitating chronic diseases
resulting from a complex interplay between gene variants and environmental factors …

Kleefstra syndrome (KS) is a neurodevelopmental disorder caused by mutations in the
histone methyltransferase EHMT1. To study the impact of decreased EHMT1 function in …

Background In light of the vulnerability of the developing brain, mixture risk assessment
(MRA) for the evaluation of developmental neurotoxicity (DNT) should be implemented …

Halogenated persistent organic pollutants (POPs) like perfluorinated alkylated substances
(PFASs), brominated flame retardants (BFRs), organochlorine pesticides and …

Human induced pluripotent stem cells (hiPSC) provide an attractive tool to study disease
mechanisms of neurodevelopmental disorders such as schizophrenia. A pertinent problem …

Autism Spectrum Disorders (ASD) affect around 1.5% of the global population, which
manifest alterations in communication and socialization, as well as repetitive behaviors or …

Induced pluripotent stem cells (iPSCs) are a valuable resource for neurological disease-
modeling and drug discovery due to their ability to differentiate into neurons reflecting the …

Myoclonus dystonia is a childhood-onset hyperkinetic movement disorder with a combined
motor and psychiatric phenotype. It represents one of the few autosomal dominant inherited …

The development of the brain is shaped by a myriad of factors among which
neurotransmitters play remarkable roles before and during the formation and maturation of …