Pathogenesis and virulence of herpes simplex virus
S Zhu, A Viejo-Borbolla - Virulence, 2021 - Taylor & Francis
Two of the most prevalent human viruses worldwide, herpes simplex virus type 1 and type 2
(HSV-1 and HSV-2, respectively), cause a variety of diseases, including cold sores, genital …
(HSV-1 and HSV-2, respectively), cause a variety of diseases, including cold sores, genital …
Mammalian stress granules and P bodies at a glance
Stress granules (SGs) and processing bodies (PBs) are membraneless ribonucleoprotein-
based cellular compartments that assemble in response to stress. SGs and PBs form …
based cellular compartments that assemble in response to stress. SGs and PBs form …
Evasion of type I interferon by SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication and host
immune response determine coronavirus disease 2019 (COVID-19), but studies evaluating …
immune response determine coronavirus disease 2019 (COVID-19), but studies evaluating …
BCG vaccination stimulates integrated organ immunity by feedback of the adaptive immune response to imprint prolonged innate antiviral resistance
Abstract Bacille Calmette–Guérin (BCG) vaccination can confer nonspecific protection
against heterologous pathogens. However, the underlying mechanisms remain mysterious …
against heterologous pathogens. However, the underlying mechanisms remain mysterious …
The integrated stress response
In response to diverse stress stimuli, eukaryotic cells activate a common adaptive pathway,
termed the integrated stress response (ISR), to restore cellular homeostasis. The core event …
termed the integrated stress response (ISR), to restore cellular homeostasis. The core event …
Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals
Mitochondrial stress activates a mitonuclear response to safeguard and repair mitochondrial
function and to adapt cellular metabolism to stress. Using a multiomics approach in …
function and to adapt cellular metabolism to stress. Using a multiomics approach in …
[HTML][HTML] mRNA-based therapeutics—developing a new class of drugs
In vitro transcribed (IVT) mRNA has recently come into focus as a potential new drug class to
deliver genetic information. Such synthetic mRNA can be engineered to transiently express …
deliver genetic information. Such synthetic mRNA can be engineered to transiently express …
mRNA vaccine delivery using lipid nanoparticles
mRNA vaccines elicit a potent immune response including antibodies and cytotoxic T cells.
mRNA vaccines are currently evaluated in clinical trials for cancer immunotherapy …
mRNA vaccines are currently evaluated in clinical trials for cancer immunotherapy …
Innate immunity to influenza virus infection
A Iwasaki, PS Pillai - Nature Reviews Immunology, 2014 - nature.com
Influenza viruses are a major pathogen of both humans and animals. Recent studies using
gene-knockout mice have led to an in-depth understanding of the innate sensors that detect …
gene-knockout mice have led to an in-depth understanding of the innate sensors that detect …
Middle East respiratory syndrome coronavirus (MERS‐CoV): infection, immunological response, and vaccine development
A Mubarak, W Alturaiki… - Journal of immunology …, 2019 - Wiley Online Library
Middle East respiratory syndrome coronavirus (MERS‐CoV) first emerged in late 2012.
Since its emergence, a total of 2279 patients from 27 countries have been infected across …
Since its emergence, a total of 2279 patients from 27 countries have been infected across …