Viral contamination is a potential risk of using biotechnology products derived from
mammalian cell lines. Therefore, to provide assurance of the safety of these products …

Background Nanofiltration entails the filtering of protein solutions through membranes with
pores of nanometric sizes that have the capability to effectively retain a wide range of …

Mille-feuille (“a thousand leaves”) paper is the first non-woven, wet-laid filter paper,
composed of 100% native cellulose, which is capable of removal of the “worst-case” model …

The goal of this work is to demonstrate how the pore-size distribution of the nanocellulose-
based virus-retentive filter can be tailored. The filter paper was produced using cellulose …

Virus filtration and ultrafiltration are critical technologies that play unique roles in all antibody
purification processes. The need to remove both retroviral as well as potential adventitious …

Viral clearance is a critical aspect of biopharmaceutical manufacturing process validation.
To determine the viral clearance efficacy of downstream chromatography and filtration steps …

Virus reference materials are needed to develop and calibrate detection devices and
instruments. We used electrospray differential mobility analysis (ES-DMA) and quantitative …

This is a comprehensive guide to single-stranded RNA phages (family Leviviridae), first
discovered in 1961. These phages played a unique role in early studies of molecular …

Ensuring the absence of detectable viruses in biopharmaceutical products is imperative from
both a regulatory and patient safety standpoint. Biopharmaceutical viral safety is the result of …

Virus filtration is used extensively in mammalian cell culture derived biopharmaceutical
manufacturing processes. This processing step relies on bench scale models that require …