There are approximately 800 annotated G protein–coupled receptor (GPCR) genes, making
these membrane receptors members of the most abundant gene family in the human …

The term “pharmacological chaperone” was introduced 20 years ago. Since then the
approach with this type of drug has been proposed for several diseases, lysosomal storage …

In men with type 2 diabetes mellitus (T2DM), steroidogenesis and spermatogenesis are
impaired. Metformin and the agonists of luteinizing hormone/human chorionic gonadotropin …

Allosteric regulation is critical for the functioning of G protein-coupled receptors (GPCRs)
and their signaling pathways. Endogenous allosteric regulators of GPCRs are simple ions …

Protein misfolding induced by missense mutations is the source of hundreds of
conformational diseases. The cell quality control may eliminate nascent misfolded proteins …

Gonadotropins regulate reproductive functions by binding to G protein-coupled receptors
(FSHR and LHCGR) expressed in the gonads. They activate multiple, cell-specific signalling …

The thyrotropin receptor (TSHR), the lutropin-(LHR), and the follicotropin receptor (FSHR)
belong to glycoprotein hormone receptors (GPHR), a subgroup of the class A G-protein …

Hypergonadotropic hypogonadism is a major feature of Klinefelter syndrome (KS), assumed
to be caused by testicular hormone resistance. It was previously shown that intratesticular …

As one of the largest families of cell membrane proteins, G protein-coupled receptors
(GPCRs) are involved in regulating almost all physiological processes by transducing …

The burden of age-related androgen deficiency and hypogonadism in men with diabetes
has become a major health problem. This is partly due to the prevalence in the population …