The expression of pattern-recognition receptors (PRRs) by immune and tissue cells provides
the host with the ability to detect and respond to infection by viruses and other …

Ebola and Marburg viruses are the only members of the Filoviridae family (order
Mononegavirales), a group of viruses characterized by a linear, non-segmented, single …

Type I Interferons (IFN-Is) are a family of cytokines which play a major role in inhibiting viral
infection. Resultantly, many viruses have evolved mechanisms in which to evade the IFN-I …

Background Ebolavirus species Zaire (ZEBOV) causes highly lethal hemorrhagic fever,
resulting in the death of 90% of patients within days. Most information on immune responses …

The cytoplasmic pattern recognition receptor RIG-I is activated by viral RNA and induces
type I IFN responses to control viral replication. The cellular dsRNA binding protein PACT …

ABSTRACT The Ebola virus (EBOV) VP35 protein antagonizes the early antiviral alpha/beta
interferon (IFN-α/β) response. We previously demonstrated that VP35 inhibits the virus …

Abstract Ebola viral protein 35 (VP35), encoded by the highly pathogenic Ebola virus,
facilitates host immune evasion by antagonizing antiviral signaling pathways, including …

Type I interferons bind to cell surface receptors composed of the subunits IFNAR1 and
IFNAR2, the intracellular domains (ICDs) of which are associated with the kinases TYK2 and …

Ebola Zaire virus is highly pathogenic for humans, with case fatality rates approaching 90%
in large outbreaks in Africa. The virus replicates in macrophages and dendritic cells (DCs) …

Previous studies have demonstrated that Marburg viruses (MARV) and Ebola viruses
(EBOV) inhibit interferon (IFN)-α/β signaling but utilize different mechanisms. EBOV inhibits …