Post-translational modification control of innate immunity

J Liu, C Qian, X Cao - Immunity, 2016 - cell.com
A coordinated balance between the positive and negative regulation of pattern-recognition
receptor (PRR)-initiated innate inflammatory responses is required to ensure the most …

Naringenin as a potential immunomodulator in therapeutics

W Zeng, L Jin, F Zhang, C Zhang, W Liang - Pharmacological research, 2018 - Elsevier
Naringenin, a citrus flavonoid that possesses various biological activities, has emerged as a
potential therapeutic agent for the management of a variety of diseases. Studies using cell …

Synchronization of secretory protein traffic in populations of cells

G Boncompain, S Divoux, N Gareil, H De Forges… - Nature …, 2012 - nature.com
To dissect secretory traffic, we developed the retention using selective hooks (RUSH)
system. RUSH is a two-state assay based on the reversible interaction of a hook protein …

Cytokine release from innate immune cells: association with diverse membrane trafficking pathways

P Lacy, JL Stow - Blood, The Journal of the American Society of …, 2011 - ashpublications.org
Cytokines released from innate immune cells play key roles in the regulation of the immune
response. These intercellular messengers are the source of soluble regulatory signals that …

The macrophage response towards LPS and its control through the p38MAPK–STAT3 axis

JG Bode, C Ehlting, D Häussinger - Cellular signalling, 2012 - Elsevier
In macrophages detection of gram-negative bacteria particularly involves binding of the
outer-wall component lipopolysaccharide (LPS) to its cognate receptor complex, comprising …

Tumor necrosis factor signaling requires iRhom2 to promote trafficking and activation of TACE

C Adrain, M Zettl, Y Christova, N Taylor, M Freeman - Science, 2012 - science.org
The cytokine tumor necrosis factor (TNF) is the primary trigger of inflammation. Like many
extracellular signaling proteins, TNF is synthesized as a transmembrane protein; the active …

Immunological significance of HMGB1 post-translational modification and redox biology

MS Kwak, HS Kim, B Lee, YH Kim, M Son… - Frontiers in …, 2020 - frontiersin.org
Most extracellular proteins are secreted via the classical endoplasmic reticulum (ER)/Golgi-
dependent secretion pathway; however, some proteins, including a few danger-associated …

Cytokine secretion in macrophages: SNAREs, Rabs, and membrane trafficking

RZ Murray, JL Stow - Frontiers in immunology, 2014 - frontiersin.org
Macrophages have the capacity to rapidly secrete a wide range of inflammatory mediators
that influence the development and extent of an inflammatory response. Newly synthesized …

Pathways for cytokine secretion

AC Stanley, P Lacy - Physiology, 2010 - journals.physiology.org
Cytokine secretion is a widely studied process, although little is known regarding the specific
mechanisms that regulate cytokine release. Recent findings have shed light on some of the …

The p38/MK2-driven exchange between tristetraprolin and HuR regulates AU–rich element–dependent translation

C Tiedje, N Ronkina, M Tehrani, S Dhamija, K Laass… - 2012 - journals.plos.org
TNF expression of macrophages is under stringent translational control that depends on the
p38 MAPK/MK2 pathway and the AU–rich element (ARE) in the TNF mRNA. Here, we …