Post-translational modification control of innate immunity
J Liu, C Qian, X Cao - Immunity, 2016 - cell.com
A coordinated balance between the positive and negative regulation of pattern-recognition
receptor (PRR)-initiated innate inflammatory responses is required to ensure the most …
receptor (PRR)-initiated innate inflammatory responses is required to ensure the most …
Naringenin as a potential immunomodulator in therapeutics
Naringenin, a citrus flavonoid that possesses various biological activities, has emerged as a
potential therapeutic agent for the management of a variety of diseases. Studies using cell …
potential therapeutic agent for the management of a variety of diseases. Studies using cell …
Synchronization of secretory protein traffic in populations of cells
G Boncompain, S Divoux, N Gareil, H De Forges… - Nature …, 2012 - nature.com
To dissect secretory traffic, we developed the retention using selective hooks (RUSH)
system. RUSH is a two-state assay based on the reversible interaction of a hook protein …
system. RUSH is a two-state assay based on the reversible interaction of a hook protein …
Cytokine release from innate immune cells: association with diverse membrane trafficking pathways
Cytokines released from innate immune cells play key roles in the regulation of the immune
response. These intercellular messengers are the source of soluble regulatory signals that …
response. These intercellular messengers are the source of soluble regulatory signals that …
The macrophage response towards LPS and its control through the p38MAPK–STAT3 axis
JG Bode, C Ehlting, D Häussinger - Cellular signalling, 2012 - Elsevier
In macrophages detection of gram-negative bacteria particularly involves binding of the
outer-wall component lipopolysaccharide (LPS) to its cognate receptor complex, comprising …
outer-wall component lipopolysaccharide (LPS) to its cognate receptor complex, comprising …
Tumor necrosis factor signaling requires iRhom2 to promote trafficking and activation of TACE
C Adrain, M Zettl, Y Christova, N Taylor, M Freeman - Science, 2012 - science.org
The cytokine tumor necrosis factor (TNF) is the primary trigger of inflammation. Like many
extracellular signaling proteins, TNF is synthesized as a transmembrane protein; the active …
extracellular signaling proteins, TNF is synthesized as a transmembrane protein; the active …
Immunological significance of HMGB1 post-translational modification and redox biology
MS Kwak, HS Kim, B Lee, YH Kim, M Son… - Frontiers in …, 2020 - frontiersin.org
Most extracellular proteins are secreted via the classical endoplasmic reticulum (ER)/Golgi-
dependent secretion pathway; however, some proteins, including a few danger-associated …
dependent secretion pathway; however, some proteins, including a few danger-associated …
Cytokine secretion in macrophages: SNAREs, Rabs, and membrane trafficking
Macrophages have the capacity to rapidly secrete a wide range of inflammatory mediators
that influence the development and extent of an inflammatory response. Newly synthesized …
that influence the development and extent of an inflammatory response. Newly synthesized …
Pathways for cytokine secretion
AC Stanley, P Lacy - Physiology, 2010 - journals.physiology.org
Cytokine secretion is a widely studied process, although little is known regarding the specific
mechanisms that regulate cytokine release. Recent findings have shed light on some of the …
mechanisms that regulate cytokine release. Recent findings have shed light on some of the …
The p38/MK2-driven exchange between tristetraprolin and HuR regulates AU–rich element–dependent translation
TNF expression of macrophages is under stringent translational control that depends on the
p38 MAPK/MK2 pathway and the AU–rich element (ARE) in the TNF mRNA. Here, we …
p38 MAPK/MK2 pathway and the AU–rich element (ARE) in the TNF mRNA. Here, we …