Pathogen perception and signaling in plant immunity

PN Dodds, J Chen, MA Outram - The Plant Cell, 2024 - academic.oup.com
Plant diseases are a constant and serious threat to agriculture and ecological biodiversity.
Plants possess a sophisticated innate immunity system capable of detecting and responding …

Effector identification in plant pathogens

AH Lovelace, S Dorhmi, MT Hulin, Y Li… - …, 2023 - Am Phytopath Society
Effectors play a central role in determining the outcome of plant− pathogen interactions. As
key virulence proteins, effectors are collectively indispensable for disease development. By …

Prediction of effector protein structures from fungal phytopathogens enables evolutionary analyses

K Seong, KV Krasileva - Nature Microbiology, 2023 - nature.com
Elucidating the similarity and diversity of pathogen effectors is critical to understand their
evolution across fungal phytopathogens. However, rapid divergence that diminishes …

A potato late blight resistance gene protects against multiple Phytophthora species by recognizing a broadly conserved RXLR-WY effector

X Lin, A Olave-Achury, R Heal, M Pais, K Witek… - Molecular Plant, 2022 - cell.com
Species of the genus Phytophthora, the plant killer, cause disease and reduce yields in
many crop plants. Although many Resistance to Phytophthora infestans (Rpi) genes …

Leveraging coevolutionary insights and AI-based structural modeling to unravel receptor–peptide ligand-binding mechanisms

S Snoeck, HK Lee, MW Schmid, KW Bender… - Proceedings of the …, 2024 - pnas.org
Secreted signaling peptides are central regulators of growth, development, and stress
responses, but specific steps in the evolution of these peptides and their receptors are not …

The NLR immune receptor ADR1 and lipase-like proteins EDS1 and PAD4 mediate stomatal immunity in Nicotiana benthamiana and Arabidopsis

H Wang, S Song, S Gao, Q Yu, H Zhang, X Cui… - The Plant …, 2024 - academic.oup.com
In the presence of pathogenic bacteria, plants close their stomata to prevent pathogen entry.
Intracellular nucleotide-binding leucine-rich repeat (NLR) immune receptors recognize …

Structural polymorphisms within a common powdery mildew effector scaffold as a driver of coevolution with cereal immune receptors

Y Cao, F Kümmel, E Logemann… - Proceedings of the …, 2023 - National Acad Sciences
In plants, host–pathogen coevolution often manifests in reciprocal, adaptive genetic
changes through variations in host nucleotide-binding leucine-rich repeat immune receptors …

[HTML][HTML] Pathways to engineering plant intracellular NLR immune receptors

R Zdrzałek, C Stone, JC De la Concepcion… - Current Opinion in Plant …, 2023 - Elsevier
Factors including climate change and increased global exchange are set to escalate the
prevalence of plant diseases, posing an unprecedented threat to global food security and …

A pathogen effector FOLD diversified in symbiotic fungi

A Teulet, C Quan, E Evangelisti, A Wanke… - New …, 2023 - Wiley Online Library
Pathogenic fungi use secreted effector proteins to suppress immunity and support their
infection, but effectors have also been reported from fungi that engage in nutritional …

Pathogen protein modularity enables elaborate mimicry of a host phosphatase

H Li, J Wang, TA Kuan, B Tang, L Feng, J Wang… - Cell, 2023 - cell.com
Pathogens produce diverse effector proteins to manipulate host cellular processes.
However, how functional diversity is generated in an effector repertoire is poorly understood …