Drug-resistant epilepsy affects approximately one-third of the patients with epilepsy. The
pharmacoresistant condition in epilepsy is mainly explained by six hypotheses. In addition …

Studies of epilepsy in mutant mice provide a framework for understanding critical features of
the brain that regulate excitability. These, and as yet undiscovered, mouse mutants will …

Changes of emotional behavior and neuronal cell loss in the hippocampus were
investigated after pentylenetetrazol (PTZ) induced kindling in rats. Behavioral and …

Previous studies demonstrated that pentylenetetrazole (PTZ), a GABA type A receptor
(GABA AR) antagonist, elicits seizure-like phenotypes in larval zebrafish (Danio rerio). Here …

Epilepsy is a chronic neurological disease characterized by recurrent behavioral seizures
and affects approximately 1% of the global population. Epilepsy causes recurrent behavioral …

Humulus lupulus (hops) is traditionally used as a tranquilizing herbal remedy. Here, we
investigated the in vivo and in vitro effect of hop β-acids on central nervous system function …

Epilepsy is a prolonged, progressively advancing nervous and psychiatric disorder of
various etiologies, characterized by paroxysmal and relatively persistent psychological …

Tetramethylenedisulfotetramine (tetramine; TETS) is a potent convulsant poison that is
considered to be a chemical threat agent. To provide a basis for the investigation of …

[Frontiers in Bioscience 5, e124-152, November 1, 2000] 124 TREATMENT OF EPILEPSY:
EXISTING THERAPIES AND FUTURE DEVELOPMENTS Si Page 1 [Frontiers in Bioscience 5 …

Increased neuronal nitric oxide synthase (nNOS) activity was observed during the prodromal
period of seizures in various rat brain regions following administration of GABAA receptor …