Sphingosine-1-phosphate (S1P) and S1P signaling pathway modulators, from current insights to future perspectives
GÁ Bravo, RR Cedeño, MP Casadevall… - Cells, 2022 - mdpi.com
Sphingosine-1-phosphate (S1P) and S1P receptors (S1PR) are bioactive lipid molecules
that are ubiquitously expressed in the human body and play an important role in the immune …
that are ubiquitously expressed in the human body and play an important role in the immune …
Targeting the S1P receptor signaling pathways as a promising approach for treatment of autoimmune and inflammatory diseases
B Stepanovska, A Huwiler - Pharmacological research, 2020 - Elsevier
The past two decades of intense research have revealed a key role of the sphingolipid
molecule sphingosine 1-phosphate (S1P) in regulating multiple physiological and …
molecule sphingosine 1-phosphate (S1P) in regulating multiple physiological and …
General copper‐catalyzed transformations of functional groups from arylboronic acids in water
A simple and general copper‐catalyzed method has been developed for transformations of
various functional groups ( I, N3, SO2R, OH, NH2, and NO2) on aromatic rings …
various functional groups ( I, N3, SO2R, OH, NH2, and NO2) on aromatic rings …
Synthesis, X-ray diffraction analysis, quantum chemical studies and α-amylase inhibition of probenecid derived S-alkylphthalimide-oxadiazole-benzenesulfonamide …
Abstract Sulphonamide and 1, 3, 4-oxadiazole moieties are present as integral structural
parts of many drugs and pharmaceuticals. Taking into account the significance of these …
parts of many drugs and pharmaceuticals. Taking into account the significance of these …
Therapeutic potential of SphK1 inhibitors based on abnormal expression of SphK1 in inflammatory immune related-diseases
Y Bu, H Wu, R Deng, Y Wang - Frontiers in Pharmacology, 2021 - frontiersin.org
Sphingosine kinase 1 (SphK1) a key enzyme that catalyzes the conversion of sphingosine
(Sph) to sphingosine 1-phosphate (S1P), so as to maintain the dynamic balance of …
(Sph) to sphingosine 1-phosphate (S1P), so as to maintain the dynamic balance of …
Sphingosine 1-phosphate signaling during infection and immunity
S Mohammed, A Bindu, A Viswanathan… - Progress in Lipid …, 2023 - Elsevier
Sphingolipids are essential components of all eukaryotic membranes. The bioactive
sphingolipid molecule, Sphingosine 1-Phosphate (S1P), regulates various important …
sphingolipid molecule, Sphingosine 1-Phosphate (S1P), regulates various important …
Importance of sphingosine kinase (SphK) as a target in developing cancer therapeutics and recent developments in the synthesis of novel SphK inhibitors …
Sphingosine kinase (SphK) is an oncogenic lipid kinase that regulates the sphingolipid
metabolic pathway that has been shown to play a role in numerous hyperproliferative …
metabolic pathway that has been shown to play a role in numerous hyperproliferative …
Structure− activity relationship studies and in vivo activity of guanidine-based sphingosine kinase inhibitors: discovery of sphK1-and sphK2-selective inhibitors
NN Patwardhan, EA Morris, Y Kharel… - Journal of medicinal …, 2015 - ACS Publications
Sphingosine 1-phosphate (S1P) is a pleiotropic signaling molecule that acts as a ligand for
five G-protein coupled receptors (S1P1–5) whose downstream effects are implicated in a …
five G-protein coupled receptors (S1P1–5) whose downstream effects are implicated in a …
Cobalt-catalyzed Kumada coupling forming sterically encumbered C–C bonds
JA Killion, WT Darrow, MR Brennan, CA Leahy… - …, 2021 - ACS Publications
A Co (acac) 3/PN precatalyst was developed and optimized for catalytic Kumada coupling of
aryl Grignard reagents to sterically encumbered alkyl halides. The substrate scope …
aryl Grignard reagents to sterically encumbered alkyl halides. The substrate scope …
Discovery, biological evaluation, and structure− activity relationship of amidine based sphingosine kinase inhibitors
Sphingosine 1-phosphate (S1P), a potent phospholipid growth and trophic factor, is
synthesized in vivo by two sphingosine kinases. Thus these kinases have been proposed as …
synthesized in vivo by two sphingosine kinases. Thus these kinases have been proposed as …