The goal of contemporary research in pemphigus vulgaris and pemphigus foliaceus is to
achieve and maintain clinical remission without corticosteroids. Recent advances of …

The MYC oncogene is a multifunctional protein that is aberrantly expressed in a significant
fraction of tumors from diverse tissue origins. Because of its multifunctional nature, it has …

Activated oncogenes induce compensatory tumour-suppressive responses, such as cellular
senescence or apoptosis, but the signals determining the main outcome remain to be fully …

Here, we show that CDK2, an S-phase cyclin-dependent kinase, is a novel target for Akt
during cell cycle progression and apoptosis. Akt phosphorylates CDK2 at threonine 39 …

Until recently, the p53 transcriptional target p21, a member of the Cip/Kip family, was almost
solely viewed as a nuclear protein with a principal function of inhibiting cyclin-dependent …

MYC oncoproteins deliver a potent oncogenic stimulus in several human cancers, making
them major targets for drug development, but efforts to deliver clinically practical …

ABSTRACT C-myc is an oncogene that functions both in the stimulation of cell proliferation
and in and apoptosis. C-myc elicits its oncogenic activity by causing immortalization, and to …

The c-Myc protein, encoded by c-myc gene, in its wild-type form can induce tumors with a
high frequency and can induce massive programmed cell death (PCD) in most transgenic …

Oral Diseases (2012) 18, 442–458 Pemphigus vulgaris (PV) is the most common type of
pemphigus. PV pathogenesis is still debated, and treatment remains challenging. We …

Up-regulation of cyclin-dependent protein kinase 2 (Cdk2) activity has been suggested to be
prerequisite for progression of apoptosis induced by various apoptotic stimuli. In this study …