Fluorescent proteins and genetically encoded biosensors
M Wang, Y Da, Y Tian - Chemical Society Reviews, 2023 - pubs.rsc.org
The genetically encoded fluorescent sensors convert chemical and physical signals into
light. They are powerful tools for the visualisation of physiological processes in living cells …
light. They are powerful tools for the visualisation of physiological processes in living cells …
[HTML][HTML] Advances in protein structure prediction and design
The prediction of protein three-dimensional structure from amino acid sequence has been a
grand challenge problem in computational biophysics for decades, owing to its intrinsic …
grand challenge problem in computational biophysics for decades, owing to its intrinsic …
Competing protein-RNA interaction networks control multiphase intracellular organization
Liquid-liquid phase separation (LLPS) mediates formation of membraneless condensates
such as those associated with RNA processing, but the rules that dictate their assembly …
such as those associated with RNA processing, but the rules that dictate their assembly …
Nano-optogenetic engineering of CAR T cells for precision immunotherapy with enhanced safety
Chimeric antigen receptor (CAR) T cell-based immunotherapy, approved by the US Food
and Drug Administration, has shown curative potential in patients with haematological …
and Drug Administration, has shown curative potential in patients with haematological …
Optogenetics at the presynapse
Optogenetic actuators enable highly precise spatiotemporal interrogation of biological
processes at levels ranging from the subcellular to cells, circuits and behaving organisms …
processes at levels ranging from the subcellular to cells, circuits and behaving organisms …
Engineered allostery in light-regulated LOV-Turbo enables precise spatiotemporal control of proximity labeling in living cells
The incorporation of light-responsive domains into engineered proteins has enabled control
of protein localization, interactions and function with light. We integrated optogenetic control …
of protein localization, interactions and function with light. We integrated optogenetic control …
Liquid nuclear condensates mechanically sense and restructure the genome
Phase transitions involving biomolecular liquids are a fundamental mechanism underlying
intracellular organization. In the cell nucleus, liquid-liquid phase separation of intrinsically …
intracellular organization. In the cell nucleus, liquid-liquid phase separation of intrinsically …
Mitochondrial control of microglial phagocytosis by the translocator protein and hexokinase 2 in Alzheimer's disease
Microglial phagocytosis is an energetically demanding process that plays a critical role in
the removal of toxic protein aggregates in Alzheimer's disease (AD). Recent evidence …
the removal of toxic protein aggregates in Alzheimer's disease (AD). Recent evidence …
VPS13D bridges the ER to mitochondria and peroxisomes via Miro
A Guillén-Samander, M Leonzino, MG Hanna IV… - Journal of Cell …, 2021 - rupress.org
Mitochondria, which are excluded from the secretory pathway, depend on lipid transport
proteins for their lipid supply from the ER, where most lipids are synthesized. In yeast, the …
proteins for their lipid supply from the ER, where most lipids are synthesized. In yeast, the …
[HTML][HTML] Mapping local and global liquid phase behavior in living cells using photo-oligomerizable seeds
Liquid-liquid phase separation plays a key role in the assembly of diverse intracellular
structures. However, the biophysical principles by which phase separation can be precisely …
structures. However, the biophysical principles by which phase separation can be precisely …