Sialic acids are cytoprotectors, mainly localized on the surface of cell membranes with
multiple and outstanding cell biological functions. The history of their structural analysis …

The glycan chains of vertebrate glycoconjugates are composed mostly of five-and six-
carbon sugars. One striking exception is the family of sialic acids (Sia), which are R-keto …

Sialic acids are a subset of nonulosonic acids, which are nine-carbon α-keto aldonic acids.
Natural existing sialic acid-containing structures are presented in different sialic acid forms …

The human genome encodes probably more than 20 different sialyltransferases involved in
the biosynthesis of sialylated glycoproteins and glycolipids but to date only 15 different …

Sialic acids are a family of negatively charged monosaccharides which are commonly
presented as the terminal residues in glycans of the glycoconjugates on eukaryotic cell …

Glycoproteins with O-glycosidically linked carbohydrate chains of complex structures and
functions are found in secretions and on the cell surfaces of cancer cells. The structures of O …

The ST6Gal sialyltransferase controls production of the Siaα2-6Galβ1-4GlcNAc
(Sia6LacNAc) trisaccharide, which is the ligand for the lectin CD22. Binding of CD22 to …

Modification of cell surface molecules with sialic acid is crucial for their function in many
biological processes, including cell adhesion and signal transduction. Uridine diphosphate …

The glycosyltransferase, ST6Gal-I, adds sialic acid in an α2–6 linkage to the N-glycans of
membrane and secreted glycoproteins. Up-regulation of ST6Gal-I occurs in many cancers …

Sialic acids are a diverse family of naturally occurring 2-keto-3-deoxy-nononic acids that are
involved in a wide range of biological processes. 1, 2 The C-5-amino derivative represents …