Human kidney organoids: progress and remaining challenges
R Nishinakamura - Nature Reviews Nephrology, 2019 - nature.com
Kidney organoids are regarded as important tools with which to study the development of
the normal and diseased human kidney. Since the first reports of human pluripotent stem …
the normal and diseased human kidney. Since the first reports of human pluripotent stem …
A primer on congenital anomalies of the kidneys and urinary tracts (CAKUT)
V Murugapoopathy, IR Gupta - … Journal of the American society of …, 2020 - journals.lww.com
Congenital anomalies of the kidneys and urinary tracts (CAKUT) are disorders caused by
defects in the development of the kidneys and their outflow tracts. The formation of the …
defects in the development of the kidneys and their outflow tracts. The formation of the …
[HTML][HTML] Comparative analysis and refinement of human PSC-derived kidney organoid differentiation with single-cell transcriptomics
Kidney organoids derived from human pluripotent stem cells have great utility for
investigating organogenesis and disease mechanisms and, potentially, as a replacement …
investigating organogenesis and disease mechanisms and, potentially, as a replacement …
Single cell regulatory landscape of the mouse kidney highlights cellular differentiation programs and disease targets
Determining the epigenetic program that generates unique cell types in the kidney is critical
for understanding cell-type heterogeneity during tissue homeostasis and injury response …
for understanding cell-type heterogeneity during tissue homeostasis and injury response …
A scalable organoid model of human autosomal dominant polycystic kidney disease for disease mechanism and drug discovery
Human pluripotent stem-cell-derived organoids are models for human development and
disease. We report a modified human kidney organoid system that generates thousands of …
disease. We report a modified human kidney organoid system that generates thousands of …
[HTML][HTML] Single-cell profiling reveals sex, lineage, and regional diversity in the mouse kidney
Chronic kidney disease affects 10% of the population with notable differences in ethnic and
sex-related susceptibility to kidney injury and disease. Kidney dysfunction leads to …
sex-related susceptibility to kidney injury and disease. Kidney dysfunction leads to …
Generation of human PSC-derived kidney organoids with patterned nephron segments and a de novo vascular network
Human pluripotent stem cell-derived kidney organoids recapitulate developmental
processes and tissue architecture, but intrinsic limitations, such as lack of vasculature and …
processes and tissue architecture, but intrinsic limitations, such as lack of vasculature and …
[HTML][HTML] A diabetic milieu increases ACE2 expression and cellular susceptibility to SARS-CoV-2 infections in human kidney organoids and patient cells
It is not well understood why diabetic individuals are more prone to develop severe COVID-
19. To this, we here established a human kidney organoid model promoting early hallmarks …
19. To this, we here established a human kidney organoid model promoting early hallmarks …
Single cell census of human kidney organoids shows reproducibility and diminished off-target cells after transplantation
Human iPSC-derived kidney organoids have the potential to revolutionize discovery, but
assessing their consistency and reproducibility across iPSC lines, and reducing the …
assessing their consistency and reproducibility across iPSC lines, and reducing the …
Mapping the human kidney using single-cell genomics
F Schreibing, R Kramann - Nature Reviews Nephrology, 2022 - nature.com
The field of single-cell genomics and spatial technologies is rapidly evolving and has
already provided unprecedented insights into complex tissues. Major advances have been …
already provided unprecedented insights into complex tissues. Major advances have been …