Signaling pathways in obesity: mechanisms and therapeutic interventions

X Wen, B Zhang, B Wu, H Xiao, Z Li, R Li… - Signal transduction and …, 2022 - nature.com
Obesity is a complex, chronic disease and global public health challenge. Characterized by
excessive fat accumulation in the body, obesity sharply increases the risk of several …

Circulating endocannabinoids: from whence do they come and where are they going?

CJ Hillard - Neuropsychopharmacology, 2018 - nature.com
The goal of this review is to summarize studies in which concentrations of circulating
endocannabinoids in humans have been examined in relationship to physiological …

Does stress influence sleep patterns, food intake, weight gain, abdominal obesity and weight loss interventions and vice versa?

NRW Geiker, A Astrup, MF Hjorth, A Sjödin… - Obesity …, 2018 - Wiley Online Library
Decades of research have reported only weak associations between the intakes of specific
foods or drinks and weight gain and obesity. Randomized controlled dietary intervention …

Obesity and addiction: neurobiological overlaps

ND Volkow, GJ Wang, D Tomasi, RD Baler - Obesity reviews, 2013 - Wiley Online Library
Drug addiction and obesity appear to share several properties. Both can be defined as
disorders in which the saliency of a specific type of reward (food or drug) becomes …

Reward, dopamine and the control of food intake: implications for obesity

ND Volkow, GJ Wang, RD Baler - Trends in cognitive sciences, 2011 - cell.com
The ability to resist the urge to eat requires the proper functioning of neuronal circuits
involved in top-down control to oppose the conditioned responses that predict reward from …

Obesity and leptin resistance: distinguishing cause from effect

MG Myers, RL Leibel, RJ Seeley… - Trends in Endocrinology & …, 2010 - cell.com
Because leptin reduces food intake and body weight, the coexistence of elevated leptin
levels with obesity is widely interpreted as evidence of 'leptin resistance.'Indeed, obesity …

Is there a “metabolic-mood syndrome”? A review of the relationship between obesity and mood disorders

RB Mansur, E Brietzke, RS McIntyre - Neuroscience & Biobehavioral …, 2015 - Elsevier
Obesity and mood disorders are highly prevalent and co-morbid. Epidemiological studies
have highlighted the public health relevance of this association, insofar as both conditions …

Stress, eating and the reward system

TC Adam, ES Epel - Physiology & behavior, 2007 - Elsevier
An increasing number of people report concerns about the amount of stress in their life. At
the same time obesity is an escalating health problem worldwide. Evidence is accumulating …

The tempted brain eats: pleasure and desire circuits in obesity and eating disorders

KC Berridge, CY Ho, JM Richard, AG DiFeliceantonio - Brain research, 2010 - Elsevier
What we eat, when and how much, all are influenced by brain reward mechanisms that
generate “liking” and “wanting” for foods. As a corollary, dysfunction in reward circuits might …

Food and drug reward: overlapping circuits in human obesity and addiction

ND Volkow, GJ Wang, JS Fowler, D Tomasi… - Brain imaging in …, 2012 - Springer
Both drug addiction and obesity can be defined as disorders in which the saliency value of
one type of reward (drugs and food, respectively) becomes abnormally enhanced relative to …