Bacterial origins of human cell-autonomous innate immune mechanisms
The cell-autonomous innate immune system enables animal cells to resist viral infection.
This system comprises an array of sensors that, after detecting viral molecules, activate the …
This system comprises an array of sensors that, after detecting viral molecules, activate the …
CBASS to cGAS-STING: the origins and mechanisms of nucleotide second messenger immune signaling
KM Slavik, PJ Kranzusch - Annual Review of Virology, 2023 - annualreviews.org
Host defense against viral pathogens is an essential function for all living organisms. In cell-
intrinsic innate immunity, dedicated sensor proteins recognize molecular signatures of …
intrinsic innate immunity, dedicated sensor proteins recognize molecular signatures of …
TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections
The induction of type I interferons through the transcription factor interferon regulatory factor
3 (IRF3) is considered a major outcome of stimulator of interferon genes (STING) activation …
3 (IRF3) is considered a major outcome of stimulator of interferon genes (STING) activation …
Two defence systems eliminate plasmids from seventh pandemic Vibrio cholerae
M Jaskólska, DW Adams, M Blokesch - Nature, 2022 - nature.com
Horizontal gene transfer can trigger rapid shifts in bacterial evolution. Driven by a variety of
mobile genetic elements—in particular bacteriophages and plasmids—the ability to share …
mobile genetic elements—in particular bacteriophages and plasmids—the ability to share …
Cyclic GMP–AMP signalling protects bacteria against viral infection
The cyclic GMP–AMP synthase (cGAS)–STING pathway is a central component of the cell-
autonomous innate immune system in animals,. The cGAS protein is a sensor of cytosolic …
autonomous innate immune system in animals,. The cGAS protein is a sensor of cytosolic …
Phage anti-CBASS and anti-Pycsar nucleases subvert bacterial immunity
The cyclic oligonucleotide-based antiphage signalling system (CBASS) and the pyrimidine
cyclase system for antiphage resistance (Pycsar) are antiphage defence systems in diverse …
cyclase system for antiphage resistance (Pycsar) are antiphage defence systems in diverse …
Abortive infection: bacterial suicide as an antiviral immune strategy
Facing frequent phage challenges, bacteria have evolved numerous mechanisms to resist
phage infection. A commonly used phage resistance strategy is abortive infection (Abi), in …
phage infection. A commonly used phage resistance strategy is abortive infection (Abi), in …
Ubiquitin-like conjugation by bacterial cGAS enhances anti-phage defence
Abstract cGAS is an evolutionarily conserved enzyme that has a pivotal role in immune
defence against infection,–. In vertebrate animals, cGAS is activated by DNA to produce …
defence against infection,–. In vertebrate animals, cGAS is activated by DNA to produce …
Diversity and classification of cyclic-oligonucleotide-based anti-phage signalling systems
Cyclic-oligonucleotide-based anti-phage signalling systems (CBASS) are a family of
defence systems against bacteriophages (hereafter phages) that share ancestry with the …
defence systems against bacteriophages (hereafter phages) that share ancestry with the …
Bacterial cGAS-like enzymes synthesize diverse nucleotide signals
Cyclic dinucleotides (CDNs) have central roles in bacterial homeostasis and virulence by
acting as nucleotide second messengers. Bacterial CDNs also elicit immune responses …
acting as nucleotide second messengers. Bacterial CDNs also elicit immune responses …