The formation of C–aryl bonds has been the focus of intensive research over the last
decades for the construction of complex molecules from simple, readily available feedstocks …

The late‐stage modification of structurally complex peptides bears great potential for drug
discovery, crop protection, and the pharmaceutical industry, among others. Whereas …

Direct C–H bond arylation of (hetero) arenes is a very convenient approach for the synthesis
of a wide variety of molecular targets, including compounds of pharmaceutical interest and π …

The catalytic functionalization of unreactive C− H bonds has recently brought a revolution in
synthetic methodologies for the production of pharmaceuticals and natural products and for …

To improve the atom-and step-economy of organic syntheses, researchers would like to
capitalize upon the chemistry of otherwise inert carbon–hydrogen (C–H) bonds. During the …

Synthetically useful functional groups, including ketones, amides, carbamates, carboxylic
acids, aldehydes or ethers, have been identified as weakly coordinating directing groups in …

Functionalized biaryl-containing motifs are among the most valuable synthetic scaffolds in
organic chemistry with wide ranging commercial applications in pharmaceuticals, functional …

The metal-catalysed successive activation and functionalisation of sp2 C–H bonds is the at
heart of synthetic innovations for the development of C–C bond cross-coupling processes …

Significant progress has been accomplished in direct olefinations through twofold C–H bond
functionalization of arenes and heteroarenes employing readily accessible, selective and …

Ruthenium catalysts enabled C–H bond functionalizations on arenes with challenging
secondary alkyl halides. Particularly, ruthenium (II) biscarboxylate complexes proved to be …