Production of CAR T-cells by GMP-grade lentiviral vectors: latest advances and future prospects
Chimeric antigen receptor (CAR) T-cells represent a paradigm shift in cancer
immunotherapy and a new milestone in the history of oncology. In 2017, the Food and Drug …
immunotherapy and a new milestone in the history of oncology. In 2017, the Food and Drug …
Androgen receptor splice variant-7 expression emerges with castration resistance in prostate cancer
BACKGROUND. Liquid biopsies have demonstrated that the constitutively active androgen
receptor splice variant-7 (AR-V7) associates with reduced response and overall survival …
receptor splice variant-7 (AR-V7) associates with reduced response and overall survival …
Signalling strength determines proapoptotic functions of STING
Mammalian cells use cytosolic nucleic acid receptors to detect pathogens and other stress
signals. In innate immune cells the presence of cytosolic DNA is sensed by the cGAS …
signals. In innate immune cells the presence of cytosolic DNA is sensed by the cGAS …
Structural basis of the activation of c-MET receptor
The c-MET receptor is a receptor tyrosine kinase (RTK) that plays essential roles in normal
cell development and motility. Aberrant activation of c-MET can lead to both tumors growth …
cell development and motility. Aberrant activation of c-MET can lead to both tumors growth …
Mycobacterium tuberculosis differentially activates cGAS-and inflammasome-dependent intracellular immune responses through ESX-1
Cytosolic detection of microbial products is essential for the initiation of an innate immune
response against intracellular pathogens such as Mycobacterium tuberculosis (Mtb). During …
response against intracellular pathogens such as Mycobacterium tuberculosis (Mtb). During …
[HTML][HTML] Sexually dimorphic neurons in the ventromedial hypothalamus govern mating in both sexes and aggression in males
CF Yang, MC Chiang, DC Gray, M Prabhakaran… - Cell, 2013 - cell.com
Sexual dimorphisms in the brain underlie behavioral sex differences, but the function of
individual sexually dimorphic neuronal populations is poorly understood. Neuronal sexual …
individual sexually dimorphic neuronal populations is poorly understood. Neuronal sexual …
Experimental design for stable genetic manipulation in mammalian cell lines: lentivirus and alternatives
RF Shearer, DN Saunders - Genes to Cells, 2015 - Wiley Online Library
The use of third‐generation lentiviral vectors is now commonplace in most areas of basic
biology. These systems provide a fast, efficient means for modulating gene expression, but …
biology. These systems provide a fast, efficient means for modulating gene expression, but …
TRIM24 is an oncogenic transcriptional activator in prostate cancer
AC Groner, L Cato, J de Tribolet-Hardy, T Bernasocchi… - Cancer cell, 2016 - cell.com
Androgen receptor (AR) signaling is a key driver of prostate cancer (PC). While androgen-
deprivation therapy is transiently effective in advanced disease, tumors often progress to a …
deprivation therapy is transiently effective in advanced disease, tumors often progress to a …
Lymph node dendritic cells harbor inducible replication-competent HIV despite years of suppressive ART
R Banga, FA Procopio, E Lana, GT Gladkov, I Roseto… - Cell host & …, 2023 - cell.com
Although gut and lymph node (LN) memory CD4 T cells represent major HIV and simian
immunodeficiency virus (SIV) tissue reservoirs, the study of the role of dendritic cells (DCs) …
immunodeficiency virus (SIV) tissue reservoirs, the study of the role of dendritic cells (DCs) …
ARv7 represses tumor-suppressor genes in castration-resistant prostate cancer
L Cato, J de Tribolet-Hardy, I Lee, JT Rottenberg… - Cancer cell, 2019 - cell.com
Androgen deprivation therapy for prostate cancer (PCa) benefits patients with early disease,
but becomes ineffective as PCa progresses to a castration-resistant state (CRPC). Initially …
but becomes ineffective as PCa progresses to a castration-resistant state (CRPC). Initially …