Chitosan and chitosan coating nanoparticles for the treatment of brain disease
S Yu, X Xu, J Feng, M Liu, K Hu - International journal of pharmaceutics, 2019 - Elsevier
Since the application of chitosan magnetic cationic microspheres in brain drug delivery by
Gallo in 1993, chitosan has been extensively studied in brain drug delivery. As the only …
Gallo in 1993, chitosan has been extensively studied in brain drug delivery. As the only …
[HTML][HTML] Optical coherence tomography as retinal imaging biomarker of neuroinflammation/neurodegeneration in systemic disorders in adults and children
The retina and the optic nerve are considered extensions of the central nervous system
(CNS) and thus can serve as the window for evaluation of CNS disorders. Spectral domain …
(CNS) and thus can serve as the window for evaluation of CNS disorders. Spectral domain …
[HTML][HTML] Pathogenesis of SCA3 and implications for other polyglutamine diseases
HS McLoughlin, LR Moore, HL Paulson - Neurobiology of disease, 2020 - Elsevier
Tandem repeat diseases include the neurodegenerative disorders known as polyglutamine
(polyQ) diseases, caused by CAG repeat expansions in the coding regions of the respective …
(polyQ) diseases, caused by CAG repeat expansions in the coding regions of the respective …
Gait variability in spinocerebellar ataxia assessed using wearable inertial sensors
Background Quantitative assessment of severity of ataxia‐specific gait impairments from
wearable technology could provide sensitive performance outcome measures with high face …
wearable technology could provide sensitive performance outcome measures with high face …
[HTML][HTML] RNA-binding proteins Musashi and tau soluble aggregates initiate nuclear dysfunction
M Montalbano, S McAllen, N Puangmalai… - Nature …, 2020 - nature.com
Oligomeric assemblies of tau and the RNA-binding proteins (RBPs) Musashi (MSI) are
reported in Alzheimer's disease (AD). However, the role of MSI and tau interaction in their …
reported in Alzheimer's disease (AD). However, the role of MSI and tau interaction in their …
CAG Repeat Expansion in THAP11 Is Associated with a Novel Spinocerebellar Ataxia
D Tan, C Wei, Z Chen, Y Huang, J Deng… - Movement …, 2023 - Wiley Online Library
Background More than 50 loci are associated with spinocerebellar ataxia (SCA), and the
most frequent subtypes share nucleotide repeats expansion, especially CAG expansion …
most frequent subtypes share nucleotide repeats expansion, especially CAG expansion …
[HTML][HTML] Quantitative gait and balance outcomes for ataxia trials: consensus recommendations by the ataxia global initiative working group on digital-motor biomarkers
With disease-modifying drugs on the horizon for degenerative ataxias, ecologically valid,
finely granulated, digital health measures are highly warranted to augment clinical and …
finely granulated, digital health measures are highly warranted to augment clinical and …
The atlas of RNase H antisense oligonucleotide distribution and activity in the CNS of rodents and non-human primates following central administration
P Jafar-Nejad, B Powers, A Soriano… - Nucleic Acids …, 2021 - academic.oup.com
Antisense oligonucleotides (ASOs) have emerged as a new class of drugs to treat a wide
range of diseases, including neurological indications. Spinraza, an ASO that modulates …
range of diseases, including neurological indications. Spinraza, an ASO that modulates …
[HTML][HTML] Gene therapy approach with an emphasis on growth factors: theoretical and clinical outcomes in neurodegenerative diseases
The etiology of many neurological diseases affecting the central nervous system (CNS) is
unknown and still needs more effective and specific therapeutic approaches. Gene therapy …
unknown and still needs more effective and specific therapeutic approaches. Gene therapy …
Digital gait biomarkers allow to capture 1‐year longitudinal change in spinocerebellar ataxia type 3
Measures of step variability and body sway during gait have shown to correlate with clinical
ataxia severity in several cross‐sectional studies. However, to serve as a valid progression …
ataxia severity in several cross‐sectional studies. However, to serve as a valid progression …