Chitosan and chitosan coating nanoparticles for the treatment of brain disease

S Yu, X Xu, J Feng, M Liu, K Hu - International journal of pharmaceutics, 2019 - Elsevier
Since the application of chitosan magnetic cationic microspheres in brain drug delivery by
Gallo in 1993, chitosan has been extensively studied in brain drug delivery. As the only …

[HTML][HTML] Optical coherence tomography as retinal imaging biomarker of neuroinflammation/neurodegeneration in systemic disorders in adults and children

S Vujosevic, MM Parra, ME Hartnett, L O'Toole, A Nuzzi… - Eye, 2023 - nature.com
The retina and the optic nerve are considered extensions of the central nervous system
(CNS) and thus can serve as the window for evaluation of CNS disorders. Spectral domain …

[HTML][HTML] Pathogenesis of SCA3 and implications for other polyglutamine diseases

HS McLoughlin, LR Moore, HL Paulson - Neurobiology of disease, 2020 - Elsevier
Tandem repeat diseases include the neurodegenerative disorders known as polyglutamine
(polyQ) diseases, caused by CAG repeat expansions in the coding regions of the respective …

Gait variability in spinocerebellar ataxia assessed using wearable inertial sensors

VV Shah, R Rodriguez‐Labrada, FB Horak… - Movement …, 2021 - Wiley Online Library
Background Quantitative assessment of severity of ataxia‐specific gait impairments from
wearable technology could provide sensitive performance outcome measures with high face …

[HTML][HTML] RNA-binding proteins Musashi and tau soluble aggregates initiate nuclear dysfunction

M Montalbano, S McAllen, N Puangmalai… - Nature …, 2020 - nature.com
Oligomeric assemblies of tau and the RNA-binding proteins (RBPs) Musashi (MSI) are
reported in Alzheimer's disease (AD). However, the role of MSI and tau interaction in their …

CAG Repeat Expansion in THAP11 Is Associated with a Novel Spinocerebellar Ataxia

D Tan, C Wei, Z Chen, Y Huang, J Deng… - Movement …, 2023 - Wiley Online Library
Background More than 50 loci are associated with spinocerebellar ataxia (SCA), and the
most frequent subtypes share nucleotide repeats expansion, especially CAG expansion …

[HTML][HTML] Quantitative gait and balance outcomes for ataxia trials: consensus recommendations by the ataxia global initiative working group on digital-motor biomarkers

W Ilg, S Milne, T Schmitz-Hübsch, L Alcock, L Beichert… - The Cerebellum, 2023 - Springer
With disease-modifying drugs on the horizon for degenerative ataxias, ecologically valid,
finely granulated, digital health measures are highly warranted to augment clinical and …

The atlas of RNase H antisense oligonucleotide distribution and activity in the CNS of rodents and non-human primates following central administration

P Jafar-Nejad, B Powers, A Soriano… - Nucleic Acids …, 2021 - academic.oup.com
Antisense oligonucleotides (ASOs) have emerged as a new class of drugs to treat a wide
range of diseases, including neurological indications. Spinraza, an ASO that modulates …

[HTML][HTML] Gene therapy approach with an emphasis on growth factors: theoretical and clinical outcomes in neurodegenerative diseases

DGT Parambi, KS Alharbi, R Kumar, S Harilal… - Molecular …, 2022 - Springer
The etiology of many neurological diseases affecting the central nervous system (CNS) is
unknown and still needs more effective and specific therapeutic approaches. Gene therapy …

Digital gait biomarkers allow to capture 1‐year longitudinal change in spinocerebellar ataxia type 3

W Ilg, B Müller, J Faber, J van Gaalen… - Movement …, 2022 - Wiley Online Library
Measures of step variability and body sway during gait have shown to correlate with clinical
ataxia severity in several cross‐sectional studies. However, to serve as a valid progression …