Cardiovascular diseases are among the leading causes of death worldwide. Reactive
oxygen species (ROS) can act as damaging molecules but also represent central hubs in …

Animal genomes contain a code for construction of the body plan from a fertilized egg.
Understanding how genome information is deciphered to create the complex multilayered …

Cardiovascular diseases have been closely linked to abnormal epigenetic regulation. In the
context of epigenetic regulation, BRG1, a pivotal SWI/SNF chromatin remodeling enzyme …

Rationale: Only a small portion of the known heritability of cardiovascular diseases, such as
heart failure, can be explained based on single-gene mutations. Chromatin structure and …

During embryogenesis, chromatin accessibility profiles control lineage-specific gene
expression by modulating transcription, thus impacting multipotent progenitor states and …

Transcriptome remodeling in heart disease occurs through the coordinated actions of
transcription factors, histone modifications, and other chromatin features at pathology …

Background: Intracranial atherosclerotic disease (ICAD) is one of the major causes of
ischemic stroke and associated with high risk of stroke recurrence. There are no reliable and …

Expression of a cohort of disease-associated genes, some of which are active in fetal
myocardium, is considered a hallmark of transcriptional change in cardiac hypertrophy …

Proteomics experiments are as diverse as the scientists who perform them. Goals range
from the desire to understand a subcellular structure or an individual protein in greater …

Cardiovascular diseases are the leading cause of death worldwide. Changes in chromatin
structure alter gene expression and drive cardiovascular disease pathogenesis. The SET …