Platelet-activating factor (PAF) receptor and genetically engineered PAF receptor mutant mice
Platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) is a
biologically active phospholipid mediator. Although PAF was initially recognized for its …
biologically active phospholipid mediator. Although PAF was initially recognized for its …
Nitric oxide and septic shock
C Thiemermann - General Pharmacology: The Vascular System, 1997 - Elsevier
1. Nitric oxide (NO) is generated by three different isoforms of NO synthase, two of which are
expressed constitutively (in endothelium: eNOS, brain: nNOS), while one is induced by …
expressed constitutively (in endothelium: eNOS, brain: nNOS), while one is induced by …
Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation.
JR Vane, JA Mitchell, I Appleton… - Proceedings of the …, 1994 - National Acad Sciences
Cyclooxygenase (COX) converts arachidonic acid to prostaglandin H2, which is further
metabolized to prostanoids. Two isoforms of COX exist: a constitutive (COX-1) and an …
metabolized to prostanoids. Two isoforms of COX exist: a constitutive (COX-1) and an …
Bacterial translocation in cirrhotic rats stimulates eNOS-derived NO production and impairs mesenteric vascular contractility
Nitric oxide (NO) has been implicated in the arterial vasodilation and associated vascular
hyporesponsiveness to vasoconstrictors observed in liver cirrhosis. Bacteria, potent …
hyporesponsiveness to vasoconstrictors observed in liver cirrhosis. Bacteria, potent …
Pharmacodynamic profile of prostacyclin
JR Vane, RM Botting - The American journal of cardiology, 1995 - Elsevier
Since the 1930s and the discovery by von Euler of a vasoactive, lipid-soluble substance that
he erroneously assumed was generated by the prostate gland and therefore should be …
he erroneously assumed was generated by the prostate gland and therefore should be …
Heart rate variability as early marker of multiple organ dysfunction syndrome in septic patients
J Pontet, P Contreras, A Curbelo, J Medina… - Journal of critical …, 2003 - Elsevier
Purpose: To determine whether measuring heart rate variability (HRV) in a group of septic
patients without multiple organ dysfunction syndrome (MODS) made it possible to predict …
patients without multiple organ dysfunction syndrome (MODS) made it possible to predict …
Role of nitric oxide and cGMP in human septic serum-induced depression of cardiac myocyte contractility
A Kumar, R Brar, P Wang, L Dee… - American Journal …, 1999 - journals.physiology.org
Previous studies have demonstrated the existence of a circulating myocardial depressant
substance during human septic shock. We have recently identified this substance as a …
substance during human septic shock. We have recently identified this substance as a …
Aminoguanidine selectively inhibits inducible nitric oxide synthase.
MJ Griffiths, M Messent, RJ MacAllister… - British journal of …, 1993 - ncbi.nlm.nih.gov
Endotoxin induces nitric oxide synthase in vascular tissue, including rat main pulmonary
artery. Currently available agents that cause inhibition of nitric oxide synthase are relatively …
artery. Currently available agents that cause inhibition of nitric oxide synthase are relatively …
Co‐induction of nitric oxide synthase and cyclo‐oxygenase: interactions between nitric oxide and prostanoids
TA Swierkosz, JA Mitchell, TD Warner… - British journal of …, 1995 - Wiley Online Library
1 Lipopolysaccharide (LPS) co‐induces nitric oxide synthase (iNOS) and cyclo‐oxygenase
(COX‐2) in J774. 2 macrophages. Here we have used LPS‐activated J774. 2 macrophages …
(COX‐2) in J774. 2 macrophages. Here we have used LPS‐activated J774. 2 macrophages …
Beneficial effects and improved survival in rodent models of septic shock with S-methylisothiourea sulfate, a potent and selective inhibitor of inducible nitric oxide …
C Szabo, GJ Southan… - Proceedings of the …, 1994 - National Acad Sciences
Enhanced formation of nitric oxide (NO) by both the constitutive and the inducible isoforms of
NO synthase (NOS) has been implicated in the pathophysiology of a variety of diseases …
NO synthase (NOS) has been implicated in the pathophysiology of a variety of diseases …