Our understanding of the functions of the IL-1 superfamily cytokine and damage-associated
molecular pattern IL-33 continues to evolve with our understanding of homeostasis and …

Il1rl1 (also known as ST2) is a member of the IL-1 superfamily, and its only known ligand is
IL-33. ST2 exists in two forms as splice variants: a soluble form (sST2), which acts as a …

Interleukin (IL)-33 belongs to IL-1 cytokine family which is constitutively produced from the
structural and lining cells including fibroblasts, endothelial cells, and epithelial cells of skin …

Abstract Interleukin-33 (IL-33), a member of the IL-1 family, and its cognate receptor,
Interleukin-1 receptor like-1 (IL-1RL1 or ST2), are susceptibility genes for childhood asthma …

Mast cells and their mediators have been implicated in the pathogenesis of asthma and
allergy for decades. Allergic asthma is a complex chronic lung disease in which several …

Mast cells (MC s) are innate immune cells that are scattered in tissues throughout the
organism being particularly abundant at sites exposed to the environment such as the skin …

The contribution of mast cells in the microenvironment of solid malignancies remains
controversial. Here we functionally assess the impact of tumor-adjacent, submucosal mast …

Mast cells (MCs) are evolutionarily ancient innate immune cells with important roles in
protective immunity against bacteria, parasites, and venomous animals. They can be found …

Recent studies have highlighted a role for the alarmin interleukin (IL)-33 in CD4+ and CD8+
T cell activation and function, and have also revealed important distinctions. The IL-33 …

Mast cells are crucial effector cells in allergic reactions, where IgE is the best known
mechanism to trigger their degranulation and release of a vast array of allergic mediators …