To understand brain function, it is essential that we discover how cellular signaling specifies
normal and pathological brain function. In this regard, chemogenetic technologies represent …

Serotonin receptors are prevalent throughout the nervous system and the periphery, and
remain one of the most lucrative and promising drug discovery targets for disorders ranging …

It is now nearly 5 years since the last of the currently recognised 5-HT receptors was
identified in terms of its cDNA sequence. Over this period, much effort has been directed …

Serotonin (5-hydroxytryptamine, 5-HT) is probably unique among the monoamines in that its
effects are subserved by as many as 13 distinct heptahelical, G-protein-coupled receptors …

Symptoms of cognitive dysfunction like memory loss, poor concentration, impaired learning
and executive functions are characteristic features of both schizophrenia and Alzheimer's …

The introduction of atypical antipsychotics (AAPs) since the discovery of its prototypical drug
clozapine has been a revolutionary pharmacological step for treating psychotic patients as …

Atypical antipsychotic drugs have revolutionized the treatment of schizophrenia and related
disorders. The current clinically approved atypical antipsychotic drugs are characterized by …

As a result of superior efficacy and overall tolerability, atypical antipsychotic drugs have
become the treatment of choice for schizophrenia and related disorders, despite their side …

Risperidone and its active metabolite 9-OH-risperidone were compared to reference
antipsychotic drugs (haloperidol, pipamperone, fluspirilene, clozapine, zotepine) and …

The affinities of olanzapine, clozapine, haloperidol, and four potential antipsychotics were
compared on binding to the neuronal receptors of a number of neurotransmitters. In both rat …