MULTIPLE MYELOMA (MM) is a clonal B-cell neo-plasm that affects terminally differentiated
B cells (ie, plasma cells) and may proceed through different phases: an inactive phase in …

Current models of signal transduction from the antigen receptors on B and T cells still
resemble equations with several unknown elements. Data from recent knock-out …

Linker or adapter proteins provide mechanisms by which receptors can amplify and regulate
downstream effector proteins. We describe here the identification of a novel B cell linker …

A 145-kDa tyrosine-phosphorylated protein that becomes associated with Shc in response
to multiple cytokines has been purified from the murine hemopoietic cell line B6SUtA1 …

Signaling through the B cell receptor (BCR) is essential for B cell function and development.
Despite the key role of Syk in BCR signaling, little is known about the mechanism by which …

Summary An Epstein-Barr virus—encoded protein, LMP2, blocks the effects of surface
immunoglobulin (slg) cross-linking on calcium mobilization and on lytic reactivation of EBV …

The phosphoinositide phosphatase SHIP is a critical regulator of immune cell activation.
Despite considerable study, the mechanisms controlling SHIP activity to ensure balanced …

Cross-linking of the B cell antigen receptor (BCR) leads to the activation of three types of
intracellular protein tyrosine kinases. These tyrosine kinases then phosphorylate signaling …

One remarkable feature of the immune system is its capacity to maintain constant numbers
of resting immune cells despite the complex nature of signals needed throughout …

Mitogen-activated protein (MAP) kinase family members, including extracellular signal–
regulated kinase (ERK), c-Jun NH2-terminal kinase (JNK), and p38 MAP kinase, have been …