Risk stratification of childhood medulloblastoma in the molecular era: the current consensus
Historical risk stratification criteria for medulloblastoma rely primarily on clinicopathological
variables pertaining to age, presence of metastases, extent of resection, histological …
variables pertaining to age, presence of metastases, extent of resection, histological …
Medulloblastoma: from myth to molecular
V Ramaswamy, MD Taylor - Journal of Clinical Oncology, 2017 - ascopubs.org
Current therapies for medulloblastoma were introduced primarily in the 1980s and consist of
predominantly cytotoxic, nontargeted approaches. Mortality from medulloblastoma remains …
predominantly cytotoxic, nontargeted approaches. Mortality from medulloblastoma remains …
Intertumoral heterogeneity within medulloblastoma subgroups
While molecular subgrouping has revolutionized medulloblastoma classification, the extent
of heterogeneity within subgroups is unknown. Similarity network fusion (SNF) applied to …
of heterogeneity within subgroups is unknown. Similarity network fusion (SNF) applied to …
Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis
Background Patients with incomplete surgical resection of medulloblastoma are
controversially regarded as having a marker of high-risk disease, which leads to patients …
controversially regarded as having a marker of high-risk disease, which leads to patients …
A biobank of patient-derived pediatric brain tumor models
S Brabetz, SES Leary, SN Gröbner, MW Nakamoto… - Nature medicine, 2018 - nature.com
Brain tumors are the leading cause of cancer-related death in children. Genomic studies
have provided insights into molecular subgroups and oncogenic drivers of pediatric brain …
have provided insights into molecular subgroups and oncogenic drivers of pediatric brain …
Single-cell transcriptomics in medulloblastoma reveals tumor-initiating progenitors and oncogenic cascades during tumorigenesis and relapse
Progenitor heterogeneity and identities underlying tumor initiation and relapse in
medulloblastomas remain elusive. Utilizing single-cell transcriptomic analysis, we …
medulloblastomas remain elusive. Utilizing single-cell transcriptomic analysis, we …
The developmental origin of brain tumours: a cellular and molecular framework
The development of the nervous system relies on the coordinated regulation of stem cell self-
renewal and differentiation. The discovery that brain tumours contain a subpopulation of …
renewal and differentiation. The discovery that brain tumours contain a subpopulation of …
Integrative analysis of gene expression and DNA methylation through one‐class logistic regression machine learning identifies stemness features in medulloblastoma
H Lian, YP Han, YC Zhang, Y Zhao, S Yan… - Molecular …, 2019 - Wiley Online Library
Most human cancers develop from stem and progenitor cell populations through the
sequential accumulation of various genetic and epigenetic alterations. Cancer stem cells …
sequential accumulation of various genetic and epigenetic alterations. Cancer stem cells …
Molecular stratifications, biomarker candidates and new therapeutic options in current medulloblastoma treatment approaches
O Menyhárt, B Győrffy - Cancer and Metastasis Reviews, 2020 - Springer
Medulloblastoma (MB) is the most common malignant childhood tumor of the brain.
Multimodal treatment consisting of surgery, radiation therapy, and chemotherapy reduced …
Multimodal treatment consisting of surgery, radiation therapy, and chemotherapy reduced …
Childhood malignant brain tumors: balancing the bench and bedside
C Thorbinson, JP Kilday - Cancers, 2021 - mdpi.com
Simple Summary Brain tumors remain the most common childhood solid tumors, accounting
for approximately 25% of all pediatric cancers. They also represent the most common cause …
for approximately 25% of all pediatric cancers. They also represent the most common cause …