Escape from X-chromosome inactivation and sex differences in Alzheimer's disease

QH Song, KX Zhao, S Huang, T Chen… - Reviews in the …, 2024 - degruyter.com
Sex differences exist in the onset and progression of Alzheimer's disease. Globally, women
have a higher prevalence, while men with Alzheimer's disease experience earlier mortality …

Genetic heterogeneity of Alzheimer's disease: embracing research partnerships

B Nacmias, S Bagnoli, I Piaceri… - Journal of Alzheimer's …, 2018 - content.iospress.com
Studies on the genetics of Alzheimer's disease (AD) have revealed the complexity and
heterogeneity of the disease. All our studies have supported this evidence and contribute to …

The protocadherin 11X/Y (PCDH11X/Y) gene pair as determinant of cerebral asymmetry in modern Homo sapiens

TH Priddle, TJ Crow - Annals of the New York Academy of …, 2013 - Wiley Online Library
Annett's right‐shift theory proposes that human cerebral dominance (the functional and
anatomical asymmetry or torque along the antero‐posterior axis) and handedness are …

Genetics of dementia in a Finnish cohort

P Pasanen, L Myllykangas, M Pöyhönen… - European Journal of …, 2018 - nature.com
Alzheimer's disease (AD) and frontotemporal dementia (FTD) are the two most common
neurodegenerative dementias. Variants in APP, PSEN1 and PSEN2 are typically linked to …

Protocadherin 11X/Y a human-specific gene pair: an immunohistochemical survey of fetal and adult brains

TH Priddle, TJ Crow - Cerebral cortex, 2013 - academic.oup.com
Protocadherins 11X and 11Y are cell adhesion molecules of the δ1-protocadherin family.
Pcdh11X is present throughout the mammalian radiation; however, 6 million years ago …

Lack of association between protocadherin 11-X/Y (PCDH11X and PCDH11Y) polymorphisms and late onset Alzheimer's disease

A Miar, V Álvarez, AI Corao, B Alonso, M Díaz… - Brain research, 2011 - Elsevier
A recent genome-wide association study (GWA) reported a significant association between
single nucleotide polymorphisms (SNPs) at the PCDH11X gene and late-onset Alzheimer's …

Association studies of 19 candidate SNPs with sporadic Alzheimer's disease in the North Chinese Han population

Q Yuan, C Chu, J Jia - Neurological Sciences, 2012 - Springer
Genome-wide association studies (GWAS) identified multiple single-nucleotide
polymorphisms (SNPs) that are associated with the pathogenesis of Alzheimer's disease …

Machine Learning Approach to Identify Case-Control Studies on ApoE Gene Mutations Linked to Alzheimer's Disease in Italy

GF Saraceno, DM Abrego-Guandique, R Cannataro… - …, 2024 - mdpi.com
Background: An application of artificial intelligence is machine learning, which allows
computer programs to learn and create data. Methods: In this work, we aimed to evaluate the …

Lack of association between PCDH11X genetic variation and late-onset Alzheimer's disease in a Han Chinese population

ZC Wu, JT Yu, ND Wang, NN Yu, Q Zhang, W Chen… - Brain research, 2010 - Elsevier
Protocadherin 11X (Pcdh11X) has been suspected to be associated with Alzheimer's
disease through participating in the metabolism of PP1α and β-catenin or by altering the …

On the Way to Longevity: How to Combat Neuro-Degenerative Disease

P d'Alessio, R Ostan, M Capri… - Senescence and …, 2013 - books.google.com
Aging can be defined as the accumulation of unrepaired, deleterious changes occurring in
the molecules, cells, tissues and organs of the body over time generated by internal and …