This review aims at juxtaposing common versus distinct structural and functional strategies
that are applied by aptamers, riboswitches, and ribozymes/DNAzymes. Focusing on recently …

Various self-cleaving ribozymes appearing in nature catalyze the sequence-specific
intramolecular cleavage of RNA and can be engineered to catalyze cleavage of appropriate …

Motivation The recent discovery of numerous non-coding RNAs (long non-coding RNAs, in
particular) has transformed our perception about the roles of RNAs in living organisms. Our …

Nucleolytic ribozymes utilize general acid‐base catalysis to perform phosphodiester
cleavage. In most ribozyme classes, a conserved active site guanosine is positioned to act …

Inspired by recent advances on functional modification of cellulosic materials, the
crosslinking behaviors of epoxide with cellulose under the catalysis of different …

Atomic mutagenesis is the key to advance our understanding of RNA recognition and RNA
catalysis. To this end, deazanucleosides are utilized to evaluate the participation of specific …

Advancements in genome-wide sequence analysis have led to the discovery of numerous
novel bacterial non-coding RNAs (ncRNAs). These ncRNAs have been categorized into …

Ribozymes are folded catalytic RNA molecules that perform important biological functions.
Since the discovery of the first RNA with catalytic activity in 1982, a large number of …

Deazapurine nucleosides such as 3-deazaadenosine (c3A) are crucial for atomic
mutagenesis studies of functional RNAs. They were the key for our current mechanistic …

The structure and dynamics of polyanionic biomolecules, like RNA, are decisively
determined by their electric interactions with the water molecules and the counterions in the …