Research progress in toxicological effects and mechanism of aflatoxin B1 toxin

C Li, X Liu, J Wu, X Ji, Q Xu - PeerJ, 2022 - peerj.com
Fungal contamination of animal feed can severely affect the health of farm animals, and
result in considerable economic losses. Certain filamentous fungi or molds produce toxic …

A review on the relation between soil and mycotoxins: Effect of aflatoxin on field, food and finance

G Winter, L Pereg - European Journal of Soil Science, 2019 - Wiley Online Library
Soil phytopathogenic fungi are principally associated with crop diseases; however, the
effects of fungal infection may extend beyond the field to human and animal consumers …

[HTML][HTML] Acute aflatoxin B1–Induced hepatotoxicity alters gene expression and disrupts lipid and lipoprotein metabolism in rats

OA Rotimi, SO Rotimi, CU Duru, OJ Ebebeinwe… - Toxicology reports, 2017 - Elsevier
In this study, alterations in lipid metabolism associated with acute aflatoxin B1 (AFB1)
induced hepatotoxicity and gene expression changes underlying these effects were …

[HTML][HTML] Dual effects of zearalenone on aflatoxin B1–induced liver and mammary gland toxicity in pregnant and lactating rats

K Wu, S Jia, D Xue, SA Rajput, M Liu, D Qi… - … and Environmental Safety, 2022 - Elsevier
Food and feed are frequently co-contaminated with aflatoxin B1 (AFB1) and zearalenone
(ZEN). This study investigated the effects of ZEN on the AFB1–induced liver and mammary …

Rab7a-mTORC1 signaling-mediated cholesterol trafficking from the lysosome to mitochondria ameliorates hepatic lipotoxicity induced by aflatoxin B1 exposure

JX Lin, CY Xu, XM Wu, L Che, TY Li, SM Mo, DB Guo… - Chemosphere, 2023 - Elsevier
Abstract Aflatoxin B1 (AFB1) is a common contaminant in many foodstuffs and is considered
a public health concern worldwide due to its hepatotoxicity caused by lipid metabolism …

Time-course effects of acute aflatoxin B1 exposure on hepatic mitochondrial lipids and oxidative stress in rats

OA Rotimi, SO Rotimi, JM Goodrich… - Frontiers in …, 2019 - frontiersin.org
Aflatoxins are secondary metabolites of certain Aspergillus species, that contaminate staple
foods, particularly in developing countries. Aflatoxin B1 (AFB1) is the most toxic and …

LC–MS-based metabolomics: an update

ZZ Fang, FJ Gonzalez - Archives of toxicology, 2014 - Springer
Liquid chromatography–mass spectrometry (LC–MS)-based metabolomics can have a
major impact in multiple research fields, especially when combined with other technologies …

Lipidomic profiling study on neurobehavior toxicity in zebrafish treated with aflatoxin B1

Z Wang, X Li, T Wang, G Liao, J Gu, R Hou… - Science of The Total …, 2023 - Elsevier
Abstract Mycotoxin aflatoxin B1 (AFB1) has been proven to cause neurotoxicity, but its
potential interference with the normal function of brain tissue is not fully defined. As the …

Metabolomics as an emerging approach for deciphering the biological impact and toxicity of food contaminants: The case of mycotoxins

P Mandal, O Lanaridi, B Warth… - Critical Reviews in Food …, 2023 - Taylor & Francis
Exposure to mycotoxins through the dietary route occurs on a daily basis while their
deleterious effects are exhibited in the form of ailments, such as inflammation, cancer, and …

NMR-based metabolic profiles of intact zebrafish embryos exposed to aflatoxin B1 recapitulates hepatotoxicity and supports possible neurotoxicity

Z Zuberi, MNH Eeza, J Matysik, JP Berry, A Alia - Toxins, 2019 - mdpi.com
Aflatoxin B1 (AFB1) is a widespread contaminant of grains and other agricultural crops and
is globally associated with both acute toxicity and carcinogenicity. In the present study, we …