Metabolic syndrome, variously known also as syndrome X, insulin resistance, etc., is defined
by WHO as a pathologic condition characterized by abdominal obesity, insulin resistance …

ContextOverweight and obesity are increasing dramatically in the United States and most
likely contribute substantially to the burden of chronic health conditions. ObjectiveTo …

Background Sleep-disordered breathing is associated with major morbidity and mortality.
However, its prevalence has mainly been selectively studied in populations at risk for sleep …

Abstract Study Objectives Rapid eye movement (REM) sleep behavior disorder (RBD) is a
parasomnia associated with neurodegenerative synucleinopathies. Its prevalence is largely …

Prior genome-wide association studies (GWAS) of major depressive disorder (MDD) have
met with limited success. We sought to increase statistical power to detect disease loci by …

Integrating single nucleotide polymorphism (SNP) p-values from genome-wide association
studies (GWAS) across genes and pathways is a strategy to improve statistical power and …

Background Low birth weight is associated with increased rates of obesity, insulin resistance
and type 2 diabetes, but the precise mechanisms for this association remain unclear. We …

Rare genetic variants contribute to complex disease risk; however, the abundance of rare
variants in human populations remains unknown. We explored this spectrum of variation by …

Background Diagnosis of sleep-disordered breathing requires overnight recordings, such as
polygraphy or polysomnography. Considering the cost and low availability of these …

Understanding the genetic structure of human populations is of fundamental interest to
medical, forensic and anthropological sciences. Advances in high-throughput genotyping …