Adipose tissue in addition to its ability to keep lipids is now recognized as a real organ with
both metabolic and endocrine functions. Recent studies demonstrated that in obese animals …

Hypoxia has been shown to increase the aggressiveness and severity of tumor progression.
Along with chronic and acute hypoxic regions, solid tumors contain regions of cycling …

A compelling body of evidence indicates that most human solid tumors contain hypoxic
areas. Hypoxia is the consequence not only of the chaotic proliferation of cancer cells that …

Obstructive sleep apnea (OSA) is common and linked to a variety of poor health outcomes. A
key modulator of this disease is nocturnal intermittent hypoxia. There is striking …

One in eight women will develop breast cancer over their lifetime making it the most
common female cancer. The cause of breast cancer is multifactorial and includes hormonal …

Macrophages are a heterogeneous group of phagocytes that play critical roles in
inflammation, infection and tumor growth. Macrophages respond to different environmental …

The interest on a potential association between cancer and sleep-disordered breathing
(SDB) has clearly gained substantial traction over the last several years. This novel …

Purpose In vitro and animal models suggest that the physiological effects of sleep apnea
could contribute to cancer risk, yet epidemiologic studies have been inconsistent. Methods …

The growing number of patients with obstructive sleep apnea is challenging healthcare
systems worldwide. Obstructive sleep apnea is characterized by chronic intermittent …

Background Recently, increased tumor incidence and cancer-related mortality have been
reported among patients with obstructive sleep apnea (OSA). Intermittent hypoxia (IH), the …