Recombination, the exchange of DNA between maternal and paternal chromosomes during
meiosis, is an essential feature of sexual reproduction in nearly all multicellular organisms …

Over 1.66 million humans (approx. 500/100 000 population rate) and over 4.2 million dogs
(approx. 5300/100 000 population rate) are diagnosed with cancer annually in the USA. The …

The observation that small isolated populations often suffer reduced fitness from inbreeding
depression has guided conservation theory and practice for decades. However …

To identify genetic changes underlying dog domestication and reconstruct their early
evolutionary history, we generated high-quality genome sequences from three gray wolves …

The origin of domestic dogs is poorly understood [1–15], with suggested evidence of dog-
like features in fossils that predate the Last Glacial Maximum [6, 9, 10, 14, 16] conflicting with …

Advances in genome technology have facilitated a new understanding of the historical and
genetic processes crucial to rapid phenotypic evolution under domestication,. To understand …

Cancer is a common problem in dogs and although all breeds of dog and crossbred dogs
may be affected, it is notable that some breeds of pedigree dogs appear to be at increased …

Domestic dogs exhibit tremendous phenotypic diversity, including a greater variation in body
size than any other terrestrial mammal. Here, we generate a high density map of canine …

Dogs were the first domesticated species, originating at least 15,000 y ago from Eurasian
gray wolves. Dogs today consist primarily of two specialized groups—a diverse set of nearly …

The extraordinary phenotypic diversity of dog breeds has been sculpted by a unique
population history accompanied by selection for novel and desirable traits. Here we perform …