TGF-β as a key modulator of astrocyte reactivity: disease relevance and therapeutic implications

J Luo - Biomedicines, 2022 - mdpi.com
Astrocytes are essential for normal brain development and functioning. They respond to
brain injury and disease through a process referred to as reactive astrogliosis, where the …

Exosomal miRNAs as potential diagnostic biomarkers in Alzheimer's disease

I Manna, S De Benedittis, A Quattrone, D Maisano… - Pharmaceuticals, 2020 - mdpi.com
Alzheimer's disease (AD), a neurodegenerative disease, is linked to a variety of internal and
external factors present from the early stages of the disease. There are several risk factors …

Biomolecular mechanisms of epileptic seizures and epilepsy: a review

KT Sumadewi, S Harkitasari, DC Tjandra - Acta Epileptologica, 2023 - Springer
Epilepsy is a recurring neurological disease caused by the abnormal electrical activity in the
brain. This disease has caused about 50 new cases in 100,000 populations every year with …

Circulating microRNAs as potential novel diagnostic biomarkers to predict drug resistance in temporal lobe epilepsy: a pilot study

S De Benedittis, F Fortunato, C Cava… - International Journal of …, 2021 - mdpi.com
MicroRNAs (miRNAs) are small noncoding RNAs that have emerged as new potential
epigenetic biomarkers. Here, we evaluate the efficacy of six circulating miRNA previously …

Circulating miR‐146a and miR‐134 in predicting drug‐resistant epilepsy in patients with focal impaired awareness seizures

M Leontariti, M Avgeris, MS Katsarou, N Drakoulis… - …, 2020 - Wiley Online Library
Objective Epilepsy is one of the most prevalent neurologic disorders, causing serious
psychological problems and reducing quality of life. Although 20 different antiepileptic drugs …

[HTML][HTML] Miconazole exerts disease-modifying effects during epilepsy by suppressing neuroinflammation via NF-κB pathway and iNOS production

L Gong, T Zhu, C Chen, N Xia, Y Yao, J Ding, P Xu… - Neurobiology of …, 2022 - Elsevier
Neuroinflammation contributes to the generation of epilepsy and has been proposed as an
effective therapeutic target. Recent studies have uncovered the potential effects of the anti …

Cystatin B is essential for proliferation and interneuron migration in individuals with EPM 1 epilepsy

F Di Matteo, F Pipicelli, C Kyrousi, I Tovecci… - EMBO molecular …, 2020 - embopress.org
Progressive myoclonus epilepsy (PME) of Unverricht–Lundborg type (EPM 1) is an
autosomal recessive neurodegenerative disorder with the highest incidence of PME …

Expression profile of miRs in mesial temporal lobe epilepsy: systematic review

KD Yakovleva, DV Dmitrenko, IS Panina… - International Journal of …, 2022 - mdpi.com
Temporal lobe epilepsy (TLE) is one of the most common forms of focal epilepsy in children
and adults. TLE is characterized by variable onset and seizures. Moreover, this form of …

Non-coding RNAs: new biomarkers and therapeutic targets for temporal lobe epilepsy

I Manna, F Fortunato, S De Benedittis… - International Journal of …, 2022 - mdpi.com
Temporal lobe epilepsy (TLE) is the most common form of focal epilepsy; it is considered a
network disorder associated with structural changes. Incomplete knowledge of the …

A systems approach delivers a functional microRNA catalog and expanded targets for seizure suppression in temporal lobe epilepsy

MT Venø, CR Reschke, G Morris… - Proceedings of the …, 2020 - National Acad Sciences
Temporal lobe epilepsy is the most common drug-resistant form of epilepsy in adults. The
reorganization of neural networks and the gene expression landscape underlying …