Tolerance and resistance of microbial biofilms

O Ciofu, C Moser, PØ Jensen, N Høiby - Nature Reviews Microbiology, 2022 - nature.com
Chronic infections caused by microbial biofilms represent an important clinical challenge.
The recalcitrance of microbial biofilms to antimicrobials and to the immune system is a major …

Photocatalytic antimicrobials: principles, design strategies, and applications

B Ran, L Ran, Z Wang, J Liao, D Li, K Chen… - Chemical …, 2023 - ACS Publications
Nowadays, the increasing emergence of antibiotic-resistant pathogenic microorganisms
requires the search for alternative methods that do not cause drug resistance. Phototherapy …

[HTML][HTML] Antimicrobial resistance: Prevalence, economic burden, mechanisms of resistance and strategies to overcome

T Pulingam, T Parumasivam, AM Gazzali… - European Journal of …, 2022 - Elsevier
Antibiotic resistance is a major health concern globally and has been estimated to cause 10
million deaths worldwide by year 2050 if the current trend of inappropriate and excessive …

Bacterial defences: mechanisms, evolution and antimicrobial resistance

WPJ Smith, BR Wucher, CD Nadell… - Nature Reviews …, 2023 - nature.com
Throughout their evolutionary history, bacteria have faced diverse threats from other
microorganisms, including competing bacteria, bacteriophages and predators. In response …

Antidepressants can induce mutation and enhance persistence toward multiple antibiotics

Y Wang, Z Yu, P Ding, J Lu, L Mao… - Proceedings of the …, 2023 - National Acad Sciences
Antibiotic resistance is an urgent threat to global health. Antidepressants are consumed in
large quantities, with a similar pharmaceutical market share (4.8%) to antibiotics (5%). While …

[HTML][HTML] Streptomyces: The biofactory of secondary metabolites

K Alam, A Mazumder, S Sikdar, YM Zhao… - Frontiers in …, 2022 - frontiersin.org
Natural products derived from microorganisms serve as a vital resource of valuable
pharmaceuticals and therapeutic agents. Streptomyces is the most ubiquitous bacterial …

Fluoroquinolone antibiotics: Occurrence, mode of action, resistance, environmental detection, and remediation–A comprehensive review

S Bhatt, S Chatterjee - Environmental Pollution, 2022 - Elsevier
Antibiotics play an essential role in the medical healthcare world, but their widespread
usage and high prevalence have posed negative environmental consequences. During the …

Chemically modified and conjugated antimicrobial peptides against superbugs

W Li, F Separovic, NM O'Brien-Simpson… - Chemical Society …, 2021 - pubs.rsc.org
Antimicrobial resistance (AMR) is one of the greatest threats to human health that, by 2050,
will lead to more deaths from bacterial infections than cancer. New antimicrobial agents …

[HTML][HTML] Antibiotics in the clinical pipeline as of December 2022

MS Butler, IR Henderson, RJ Capon… - The Journal of …, 2023 - nature.com
The need for new antibacterial drugs to treat the increasing global prevalence of drug-
resistant bacterial infections has clearly attracted global attention, with a range of existing …

[HTML][HTML] A deep learning approach to antibiotic discovery

JM Stokes, K Yang, K Swanson, W Jin, A Cubillos-Ruiz… - Cell, 2020 - cell.com
Due to the rapid emergence of antibiotic-resistant bacteria, there is a growing need to
discover new antibiotics. To address this challenge, we trained a deep neural network …