Pathological alterations to the locus coeruleus, the major source of noradrenaline in the
brain, are histologically evident in early stages of neurodegenerative diseases. Novel MRI …

Research on cognitive aging has focused on how decline in various cortical and
hippocampal regions influence cognition. However, brainstem regions play essential …

Alzheimer's disease (AD) is the most common cause of dementia, accounting for more than
50 million patients worldwide. Current evidence suggests the exact mechanism behind this …

It has been known for decades that degeneration of the locus coeruleus (LC), the major
noradrenergic nucleus in the brain, occurs in both Alzheimer's disease (AD) and Parkinson's …

A major feature of Alzheimer's disease (AD) is the loss of noradrenergic locus coeruleus
(LC) projection neurons that mediate attention, memory, and arousal. However, the extent to …

None of the proposed mechanisms of Alzheimer's disease (AD) fully explains the distribution
patterns of the neuropathological changes at the cellular and regional levels, and their …

Extensive neuropathological studies have established a compelling link between
abnormalities in structure and function of subcortical monoaminergic (MA-ergic) systems …

It is not yet established whether oxidative stress is a major cause of cell death or simply a
consequence of an unknown pathogenetic factor. Concerning chronic diseases, as …

Neuronal loss and the presence of neurofibrillary tangles (NFTs) within aminergic nuclei
were examined in a series of patients with Alzheimer's disease (AD). Neuromelanin …

The locus coeruleus is the initial site of Alzheimer's disease neuropathology, with
hyperphosphorylated Tau appearing in early adulthood followed by neurodegeneration in …