Gain-of-function cardiomyopathic mutations in RBM20 rewire splicing regulation and re-distribute ribonucleoprotein granules within processing bodies
Mutations in the cardiac splicing factor RBM20 lead to malignant dilated cardiomyopathy
(DCM). To understand the mechanism of RBM20-associated DCM, we engineered isogenic …
(DCM). To understand the mechanism of RBM20-associated DCM, we engineered isogenic …
RBM20S639G mutation is a high genetic risk factor for premature death through RNA-protein condensates
Dilated cardiomyopathy (DCM) is a heritable and genetically heterogenous disease often
idiopathic and a leading cause of heart failure with high morbidity and mortality. DCM …
idiopathic and a leading cause of heart failure with high morbidity and mortality. DCM …
[HTML][HTML] Proteome-wide quantitative RNA-interactome capture identifies phosphorylation sites with regulatory potential in RBM20
CH Vieira-Vieira, V Dauksaite, A Sporbert, M Gotthardt… - Molecular Cell, 2022 - cell.com
Cellular mRNA-binding proteins (mRBPs) are major posttranscriptional regulators of gene
expression. Although many posttranslational modification sites in mRBPs have been …
expression. Although many posttranslational modification sites in mRBPs have been …
SR protein kinases regulate the splicing of cardiomyopathy-relevant genes via phosphorylation of the RSRSP stretch in RBM20
(1) Background: RNA binding motif 20 (RBM20) regulates mRNA splicing specifically in
muscle tissues. Missense mutations in the arginine/serine (RS) domain of RBM20 lead to …
muscle tissues. Missense mutations in the arginine/serine (RS) domain of RBM20 lead to …
RBM20-mediated pre-mRNA splicing has muscle-specificity and differential hormonal responses between muscles and in muscle cell cultures
Pre-mRNA splicing plays an important role in muscle function and diseases. The RNA
binding motif 20 (RBM20) is a splicing factor that is predominantly expressed in muscle …
binding motif 20 (RBM20) is a splicing factor that is predominantly expressed in muscle …
Quantitative investigation of protein-RNA interactions and regulation by phosphorylation
CH Vieira e Vieira - 2022 - edoc.hu-berlin.de
Post-transcriptional regulation of gene expression is fundamental in health and disease.
RNA-binding proteins (RBPs) directly bind and govern the fate of RNAs in cells. At the same …
RNA-binding proteins (RBPs) directly bind and govern the fate of RNAs in cells. At the same …
[图书][B] Quantitative investigation of protein-RNA interactions and regulation by phosphorylation
CHV e Vieira - 2021 - search.proquest.com
Post-transcriptional regulation of gene expression is fundamental in health and disease.
RNA-binding proteins (RBPs) directly bind and govern the fate of RNAs in cells. At the same …
RNA-binding proteins (RBPs) directly bind and govern the fate of RNAs in cells. At the same …