Non-alcoholic fatty liver disease (NAFLD) is currently the world's most common liver
disease, estimated to affect up to one-fourth of the population. Hallmarked by hepatic …

Alcohol is inextricably linked with the digestive system. It is absorbed through the gut and
metabolised by hepatocytes within the liver. Excessive alcohol use results in alterations to …

Childhood obesity has reached epidemic levels, representing one of the most serious public
health concerns associated with metabolic syndrome and non-alcoholic fatty liver disease …

The accelerated metabolic demands of the working muscle cannot be met without a robust
response from the liver. If not for the hepatic response, sustained exercise would be …

Hepatic steatosis, the excess storage of intrahepatic lipids, is a rampant clinical problem
associated with the obesity epidemic. Hepatic steatosis is linked to increased risk for insulin …

Non‐alcoholic fatty liver disease (NAFLD) is one of the most prevalent metabolic disorders
worldwide, along with obesity and type 2 diabetes. NAFLD involves a series of liver …

Exercise training reduces the incidence of several cancers, but the mechanisms underlying
these effects are not fully understood. Exercise training can affect the spleen function, which …

Over the last few decades, metabolic disease rates have been on the rise, and this is
partially due to older individuals (> 65 years of age) making up a higher percentage of the …

The gut is a selective barrier that not only allows the translocation of nutrients from food, but
also microbe-derived metabolites to the systemic circulation that flows through the liver …

Large-scale epidemiological studies show that low exercise capacity is the highest risk
factor for all-cause morbidity and mortality relative to other conditions including diabetes …