Neurodegeneration of the central and enteric nervous systems is a common feature of aging
and aging-related diseases, and is accelerated in individuals with metabolic dysfunction …

Oxidative stress is increasingly recognized as a central player in a range of gastrointestinal
(GI) disorders, as well as complications stemming from therapeutic interventions. This article …

Background & Aims Tachykinins are involved in physiological and pathophysiological
mechanisms in the gastrointestinal tract. The major sources of tachykinins in the gut are …

The reflexive activities of the gastrointestinal tract are regulated, in part, by precise
interactions between neurons and glia in the enteric nervous system (ENS). Intraganglionic …

Enteric neuron degeneration has been observed during aging, and in individuals with
metabolic dysfunction including obesity and diabetes. Honokiol, a naturally occurring …

There is a growing consensus that the balance between the persistence of infection and the
host immune response is crucial for chronification of Chagas heart disease. Extrapolation for …

Abstract Sirtuins 蛋白家族(Sirt 家族) 是一类高度保守的烟酰胺腺嘌呤二核苷酸(nieotinamide
adenie diueleotide, NAD+) 依赖的去乙酰化酶(histonedeacetylase, HDAC). Sirts …

Neurodegeneration of the central and enteric nervous systems is a common feature of aging
and aging-related diseases, and is accelerated in individuals with metabolic dysfunction …

Historically, major depressive disorder (MDD) has been variously conceptualized, including
as cognitive, psychoanalytical, and biological, with treatment approaches being thereby …

A doença de Chagas (DC) é uma doença tropical causada pelo Trypanosoma cruzi. Uma
das apresentações da DC crônica é a forma gastrointestinal. O megacólon foi descrito como …