Neurotransmitters—key factors in neurological and neurodegenerative disorders of the central nervous system

RI Teleanu, AG Niculescu, E Roza… - International journal of …, 2022 - mdpi.com
Neurotransmitters are molecules that amplify, transmit, and convert signals in cells, having
an essential role in information transmission throughout the nervous system. Hundreds of …

[HTML][HTML] Mitochondrial dysfunction and oxidative stress in Alzheimer's disease

A Misrani, S Tabassum, L Yang - Frontiers in aging neuroscience, 2021 - frontiersin.org
Mitochondria play a pivotal role in bioenergetics and respiratory functions, which are
essential for the numerous biochemical processes underpinning cell viability. Mitochondrial …

[HTML][HTML] Glutamate excitotoxicity: Potential therapeutic target for ischemic stroke

Z Shen, M Xiang, C Chen, F Ding, Y Wang… - Biomedicine & …, 2022 - Elsevier
Glutamate-mediated excitotoxicity is an important mechanism leading to post ischemic
stroke damage. After acute stroke, the sudden reduction in cerebral blood flow is most …

Chitosan nanoparticles: a versatile platform for biomedical applications

SM Bashir, G Ahmed Rather, A Patrício, Z Haq… - Materials, 2022 - mdpi.com
Chitosan is a biodegradable and biocompatible natural polymer that has been extensively
explored in recent decades. The Food and Drug Administration has approved chitosan for …

Calcium dyshomeostasis in Alzheimer's disease pathogenesis

R Cascella, C Cecchi - International journal of molecular sciences, 2021 - mdpi.com
Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder that
is characterized by amyloid β-protein deposition in senile plaques, neurofibrillary tangles …

Mitochondria-lysosome contacts regulate mitochondrial Ca2+ dynamics via lysosomal TRPML1

W Peng, YC Wong, D Krainc - Proceedings of the National …, 2020 - National Acad Sciences
Mitochondria and lysosomes are critical for cellular homeostasis, and dysfunction of both
organelles has been implicated in numerous diseases. Recently, interorganelle contacts …

Polyglutamine repeats in neurodegenerative diseases

AP Lieberman, VG Shakkottai… - Annual Review of …, 2019 - annualreviews.org
Among the age-dependent protein aggregation disorders, nine neurodegenerative diseases
are caused by expansions of CAG repeats encoding polyglutamine (polyQ) tracts. We …

TRPC channels: Structure, function, regulation and recent advances in small molecular probes

H Wang, X Cheng, J Tian, Y Xiao, T Tian, F Xu… - Pharmacology & …, 2020 - Elsevier
Transient receptor potential canonical (TRPC) channels constitute a group of receptor-
operated calcium-permeable nonselective cation channels of the TRP superfamily. The …

[HTML][HTML] Possible effects of radiofrequency electromagnetic field exposure on central nerve system

JH Kim, JK Lee, HG Kim, KB Kim… - Biomolecules & …, 2019 - ncbi.nlm.nih.gov
Technological advances of mankind, through the development of electrical and
communication technologies, have resulted in the exposure to artificial electromagnetic …

Altered ER–mitochondria contact impacts mitochondria calcium homeostasis and contributes to neurodegeneration in vivo in disease models

KS Lee, S Huh, S Lee, Z Wu, AK Kim… - Proceedings of the …, 2018 - National Acad Sciences
Calcium (Ca2+) homeostasis is essential for neuronal function and survival. Altered Ca2+
homeostasis has been consistently observed in neurological diseases. How Ca2+ …