Neurotransmitters—key factors in neurological and neurodegenerative disorders of the central nervous system
Neurotransmitters are molecules that amplify, transmit, and convert signals in cells, having
an essential role in information transmission throughout the nervous system. Hundreds of …
an essential role in information transmission throughout the nervous system. Hundreds of …
[HTML][HTML] Mitochondrial dysfunction and oxidative stress in Alzheimer's disease
A Misrani, S Tabassum, L Yang - Frontiers in aging neuroscience, 2021 - frontiersin.org
Mitochondria play a pivotal role in bioenergetics and respiratory functions, which are
essential for the numerous biochemical processes underpinning cell viability. Mitochondrial …
essential for the numerous biochemical processes underpinning cell viability. Mitochondrial …
[HTML][HTML] Glutamate excitotoxicity: Potential therapeutic target for ischemic stroke
Z Shen, M Xiang, C Chen, F Ding, Y Wang… - Biomedicine & …, 2022 - Elsevier
Glutamate-mediated excitotoxicity is an important mechanism leading to post ischemic
stroke damage. After acute stroke, the sudden reduction in cerebral blood flow is most …
stroke damage. After acute stroke, the sudden reduction in cerebral blood flow is most …
Chitosan nanoparticles: a versatile platform for biomedical applications
Chitosan is a biodegradable and biocompatible natural polymer that has been extensively
explored in recent decades. The Food and Drug Administration has approved chitosan for …
explored in recent decades. The Food and Drug Administration has approved chitosan for …
Calcium dyshomeostasis in Alzheimer's disease pathogenesis
R Cascella, C Cecchi - International journal of molecular sciences, 2021 - mdpi.com
Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder that
is characterized by amyloid β-protein deposition in senile plaques, neurofibrillary tangles …
is characterized by amyloid β-protein deposition in senile plaques, neurofibrillary tangles …
Mitochondria-lysosome contacts regulate mitochondrial Ca2+ dynamics via lysosomal TRPML1
Mitochondria and lysosomes are critical for cellular homeostasis, and dysfunction of both
organelles has been implicated in numerous diseases. Recently, interorganelle contacts …
organelles has been implicated in numerous diseases. Recently, interorganelle contacts …
Polyglutamine repeats in neurodegenerative diseases
AP Lieberman, VG Shakkottai… - Annual Review of …, 2019 - annualreviews.org
Among the age-dependent protein aggregation disorders, nine neurodegenerative diseases
are caused by expansions of CAG repeats encoding polyglutamine (polyQ) tracts. We …
are caused by expansions of CAG repeats encoding polyglutamine (polyQ) tracts. We …
TRPC channels: Structure, function, regulation and recent advances in small molecular probes
Transient receptor potential canonical (TRPC) channels constitute a group of receptor-
operated calcium-permeable nonselective cation channels of the TRP superfamily. The …
operated calcium-permeable nonselective cation channels of the TRP superfamily. The …
[HTML][HTML] Possible effects of radiofrequency electromagnetic field exposure on central nerve system
JH Kim, JK Lee, HG Kim, KB Kim… - Biomolecules & …, 2019 - ncbi.nlm.nih.gov
Technological advances of mankind, through the development of electrical and
communication technologies, have resulted in the exposure to artificial electromagnetic …
communication technologies, have resulted in the exposure to artificial electromagnetic …
Altered ER–mitochondria contact impacts mitochondria calcium homeostasis and contributes to neurodegeneration in vivo in disease models
KS Lee, S Huh, S Lee, Z Wu, AK Kim… - Proceedings of the …, 2018 - National Acad Sciences
Calcium (Ca2+) homeostasis is essential for neuronal function and survival. Altered Ca2+
homeostasis has been consistently observed in neurological diseases. How Ca2+ …
homeostasis has been consistently observed in neurological diseases. How Ca2+ …